Session 1

0

10

SYSTEMATIC DETECTION OF ADVERSE DRUG EFFECTS IN THE ELDERLY – PARTIAL RESULTS FROM 1279 PATIENTS

L. Véronèse1, P. Marquetl, Y. Nouaillel, J-P. Charmes2, L. Merle1

Service de Pharmacologie-Toxicologie-Centre Régional de Pharmacovigilance (1), Département de Gérontologie Clinique (2), CHU Dupuytren, 87042 Limoges, France.

In order to assess the importance of adverse drug effects (ADE) in 2000 elderlies consecutively admitted to hospital a prospective study is under way in an acute care medical unit.

From the 1279 first patients included preliminary results show this aged population (85

6 years; 70-103 years) consisting of 70 % women was taking numerous drugs (6.2 ± 3.1/day; 0-24) immediately prior to admission. Drug effects were classified as adverse {probable (21 %), possible (20 %), absent (51 %)} or not adverse raising compliance or inefficacy (8 %) problems. The number of drugs was higher in the probable ADE group (6.8 ± 2.9) than in the group without ADE (5.4 ± 3.0) (p