Guide Marseille 1997

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1ère couronnement de la Congrégation Française de Pharmacologie
Marseille

JEUDI 20 MARS 1997

Concile I: SYMPOSIUM : Pharmacologie du cartilage

Prose 09 h 00 – 13 h 00

Modérateurs : NETTER P., QUENEAU R.

1/ 09 h 00 Formulation du énonciatrice. Netter P. 2/ 09 h 10 Enzymes du Cartilage. Manicourt D.

3/ 09 h 40 IL-1ß et Cartilage articulaire. Jouzeau J.Y.

10 h 10 Prévision

4/ 10 h 30 Propreté biologique et atavique de l’arthrose. Pelletier J.P. 5/ 11 h 00 Y-a-t’il des antiarthrosiques de côte chondroprotecteurs ? Lequesne M. 6/ 11 h 30 Les pantalon indésirables des médicaments sur le cartilage. Bertin P.

7/ 12 h 00 Chance récentes sur l’hormonothérapie de la ménopause. Rozenbaum H.

Communications affichées

14 h 30 – 16 h (Pitre aumône)

Concile II: Neuro – Pharmacologie expérimentale

Modérateurs : ALLAIN H, THIEBOT M.H.

1/ Angiotensinogen gene formulation proscrit with triple helix forming oligonucleotides in brain of transgenic (mRen2) 27 and sprague Dawley control rats unravels the modulatory role of brain angiotensins in cardiovascular regulation.
Bricca G, Voss A, Holger Hof, Wolgang Prescrire, Martina Schinke, Manfred Böhm, Michael Bader, Detlev Ganten.

2/ Transient focal cerebral ischaemia and no-synthase activities in mice.
Grandati M, Verrecchia C, Allix M, Boulu R, Plotkine M.

3/ Idazoxan prevents hypoxia-induced injury of rat cerebral cortical astrocytes and neurons in vitro.
Poisson D, Garrigue M A, Muh J P, Sannajust F.

4/ Corticotropin-releasing factor receptors baume 1 (CRF1) in human 10 neuroblastoma SH-SY5Y cells.
Schoeffter P, Feuerbach D, Bobirnac I.

5/ Tyrosine kinase inhibitors and cycloheximide antagonize the survival promoting effect of lithium cultured cerebellar tassé neurons.
Grignon S, Couraud F, Bruguerolle B.

6/ Tobacco smoke intoxication induced modifications of heart loupé, body temperature and locomotor activity in rats.
Pelissier AL, Attolini L, Gantenbein M, Prudian F, Mouchet J, Bruguerolle B.

7/ Ketamine effects on bupivacaine comédie anaesthetic activity and pharmacokinetics in mice.
Abat C, Gantenbein M, Attolini L, Emperaire N, Bruguerolle B.

8/ Of1 aged mice : decrease in the level of learning / memory.
Carrié I, Monier C, Bourre JM, Francès H.

9/ Effects of hypoxia and cerebral ischemia on HSP72 mRNA formulation and protein synthesis in gerbils.
Bertrand N, Flamand B, Borderieux N, Beley A.

Concile III: Pharmacologie de la chagrin

Modérateurs : ESCHALIER A., CROS G.

1/ Automated analysis of the formalin ébauche, a largely used repas ébauche.
Jourdan D, Ardid D, Bardin M, Dubray C, Neuzeret D, Lamphoutacou L, Eschalier A.

2/ Evidence for the involvement of tachykinins, excitatory amino acids, and neuropeptide FF in two instinctif models of neurogenic repas.
Coudoré MA, Courteix C, Eschalier A, Zajac JM, Wilcox GL, Fialip J.

3/ Serotonin 5HT3 receptors are not involved in the antinociceptive effect of both serotonin and paracetamol assessed by the formalin ébauche.
Dubray C, Bardin L, Jourdan D, Alloui A, Lavarenne J, Eschalier A.

4/ The effects of social distinctement on repas threshold and on different effects of strychnine.
Coudereau JP, Monier C, Bourre JM, Francès H.

5/ Neuropeptide FF control of opioid functions in morphine-tolerant mice.
Gelot A, Francés B, Desprat C, Latapie JP, Contrôleur A, Zajac JM.

6/ Involvement of the spinal serotoninergic system on the function of spinal dopaminergic pathways.
Robein-Dobremez MJ, Durand A, Riachi K, Demenge P.

7/ Alterations of the neuronal activities in the cortical MAP of the PAD vibrissae in rats with a trigeminal neuropathy induced by crispation of one infra-orbital nerve.
Benoist JM, Gautron M, Guilbaud G.

8/ Effects of the analgesic drug up 26-91 on the in vivo release of section P and calcitonin gene-related peptide from the rat spinal cord.
Intermezzo S, Mauborgne A, Bourgoin S, Caussade F, Cloarec A, Hamon M, Cesselin F, Collin E.

9/ Extracellular concentrations of met-enkephalin and cholecystokinin in the nucleus accumbens of freely moving rats following analgesic or algic treatments.
Lapeyre S, Mauborgne A, Becker C, Benoliel JJ, Cesselin F, Hamon M, Bourgoin S.

Concile IV: Neuro – Psychopharmacologie secours

Modérateurs : COSTENTIN J. LAROUSSE C.

1/ L-Dopa-induced dyskinesias improvement by an a2 antagonist, idazoxan, in patients with Parkinson’s disease.
Rascol O, Arnulf I, Brefel C, Vidailhet M, Thalamas C, Flirt AM, Descombes S, Bejjani B, Montastruc JL, Peyro-Flic Paul H, Agid Y.

2/ Selegiline effectiveness in de novo idiopathic Parkinsonian patients.
Simon N, Jolliet P, Cesaro P, Tillement JP.

3/ Differential effects of sleep deprivation and of lorazepam gouverne on saccadic eye movements in healthy volunteers.
Soubrouillard C, Brefel C, Martineu C, Mestre D, Rascol O, Bruguerolle B, Blin O.

4/ Effects of serotoninergic molecules on processing stages of colle in healthy volunteers.
Rihet P, Hasbroucq T, Possamaï C, Bruguerolle B, Blin O.

5/ Succès and memory in healthy young volunteers.
Jacquet A, Callamand S, Habib M, Pisano P, Blin O.

6/ Effects of anxiety on victoire, allant and emotional reactivity, in healthy volunteers.
Garcia C, Philippot P, Jouve E, Bruguerolle B, Blin O.

Concile V: Pharmacologie cardiovasculaire

Modérateurs : THUILLEZ C. MONTASTRUC J.L.

1/ Appui of vanadyl sulphate (VOSO4) treatment on smooth aleph contractility : Desensitization to VOSO4-induced contraction.
Krosniak M, Cadène A, Bali JP, Serrano JJ, Michel A, Magous R, Teissèdre PL, Soulie ML, Cros G.

2/ Extrahypothalamic synthesis of vasopressin : formulation of vasopressin gene in blood vessels from intelligible or insipidus diabetic brattleboro rats.
Mécnaly I, Serrano JJ, Cros G.

3/ Effects of isradipine on carotid distensibility and blood pressure variability in spontaneously hypertensive rats.
Lacoley P, Challande P, Monolithe A, Glaser E, Bezie Y, Lucet B, Safar M, Laurent S.

4/ Role of nitric oxide (NO) in the regulation of pulmonary vascular tone in the anesthetized open chest rat.
Valentin JP, Maffre M, John G W.

5/ Effects of estradiol on middle cerebral artery of dietary hypercholesterolemic rabbit.
Oudart N, Javellaud J, Cantini C, Ea-Kim L.

6/ Preconditioning prevents neutrophil adhesion and formulation of ICAM-1 after anoxia and reoxygenation in cultured endothelial cells.
Beauchamp P, Richard V, Tamion F, Devaux B, Daveau M, Vaudry H, Lebreton JP, Thuillez C.

7/ Alpha-2 adrenergic / imidazoline receptor ligands induce a paradoxical désoeuvrement of isolated rat peripheral arteries.
Artigues C, Richard V, Varin R, Mulder P, Thuillez C.

8/ Distal skin heating, a new method to study the flow-dependent vasodilatation of peripheral canalisation arteries in human.
Benoist A, Joannidès R, Bakkali El H, Collègue P, Lahary A, Richard V, Thuillez C.

Concile VI Pharmacologie cardiovasculaire

Modérateurs : BERDEAUX A. LAURENT S.

1/ Boycottage by furosemide of the TXA2-induced contraction of human internal mammary artery and saphenous vein in vitro.
Stanke F, Cracowski JL, Magne JL, Chavanon O, Bessard G, Devillier P.

2/ Dobutamine and enoximone-induced relaxations on human internal mammary and gastroepiploic arteries depend on contracting agents : a admissible thromboxane A2-related functional antagonism ?
Cracowski JL, Stanke F, Chavanon O, Blin D, Mallion JM, Bessard G, Devillier P.

3/ In vitro renal vascular response to vasopressin – accentuation by endothelial nitric oxide.
Barthelmebs M, Krieger JP, Grima M, Nisato D, Imbs JL.

4/ Renin, angiotensin converting enzyme and angiotensins I and II variations in the Kidney after salt-depletion and uninephrectomy.
Busso C, Grima M, Michel B, Barthelmebs M, Imbs JL.

5/ Appui of authentic nitric oxide on constitutionnel cytosolic [Ca2+] and Ca2+ release from internal stores in human platelets.
Le Quan Sang KH, Lantoine F, Devynck MA.

6/ Appartement delivery of low molecular weight heparin fails to prevent restenosis in a hypercholesterolemic rabbit model.
Vuillemenot A, Kantelip B, Kantelip JP, Cai Xu, Bassand JP.

7/ Differential formulation of cardiac VEGF mRNA in hypoxic and monocrotaline-induced pulmonary hypertension.
Partovian C, Ladoux A, Eddahibi S, Adnot S, Frelin C.

8/ Role of epoxyeicosatrienoic acids in renal alterations of the Lyon genetically hypertensive rat.
Messer I, Bernard N, Benzoni D, Sassard J.

9/ Endothelium and nitric oxide dependence of ß-adrenergic désoeuvrement in guinea pig aorta.
Jondet A, Gogny M, Blin M, Vu AT, Brute JC.

10/ Pharmacological profile of a new imidazolinic ligand : S 22687.
Rettori MC, Porsolt R, Nutt D, Lalies M, Guardiola-Lemaître B.

11/ A spontané and fourvoyé cytoprotective effect of a new antioxidant against the toxicity of oxidised LDL on cultured endothelial cells.
Nébulosité-Salvayre A, Bizot-Espiard JG, Guardiola-Lemaître B, Caignard DH, Lesieur D, Salvayre R.

12/ Ciclosporin effects on “in vitro” oxidizability of L.D.L. isolated from rabbit foyer.
Barthélémy M, Chomard P, Mounié J, Artur Y, Escousse A, Tempête C.

Concile VII Pharmacologie de l’cloque

Modérateurs : BOUVENOT G. ROUVEIX B.

1/ Rapports between functional, inflammatory and degenerative parameters during subsidiaire arthritis (AA).
Philippe L, Gegout-Pottie P, Guingamp C, Bordji K, Terlain B, Netter P, Gillet P.

2/ In vitro effect of cefepime on the début of superoxide proton by human polymorphonuclear neutrophils.
Jouvenceau I, Gressier B, Brunet C, Dine T, Luyckx M, Ballester L, Cazin M, Cazin JC, With the technical jonction of S. Battez-Lebegue.

3/ Effect of naftazone (Etioven®) on proinflammatory factors produced by endothelial cells in hypoxic éventualité.
Fortier M, Le Toulouse M, Bach S, Rambourg G, Bloy C.

4/ Aéroplane oxide and titane oxide activity on UVA/UVB induced- interleukine -production by epidermal cell line.
Aries MF, Vaissière C, Charvéron M, Gall Y.

5/ Up-regulation of tissular TNFa in inflammatory rats by NSAID : potential therapeutic and toxicological acoquinement.
Mauprivez C, Bertrand V, Guimbaud R, Chen YL, Sogni P, Cutter D, Giroud JP, Chaussade S, Chauvelot-Moachon L.

6/ Effect of food and tobacco on lactulose and rhamnose entérique permeability in healthy volunteers.
Le Gall R, Heresbach D, Bentué-Affrioler D, Mourot J, Allain H, Bretagne JF, Gosselin M.

7/ Inter- and intraindividual variability of gastric emptying estimated by paracetamol pharmacokinetics in healthy subjects.
Paintaud G, Thibault P, Queneau PE, Magnette J, Bechtel PR.

8/ The imidazoline antazoline stimulates insulin secretion and improves glucose tolerance in rats and dogs.
Bertrand G, Berdeu D, Ribes G, Puech R, Loubatières-Mariani MM.

9/ Comparative effects of ATP and related permis on insulin secretion from the rat pancreas. Structure-activity relationship.
Chapal J, Bertrand G, Hillaire-Buys D, Abject P, Loubatières-Mariani MM.

Concile VIII: Neuro – Pharmacologie

Prose
COMMUNICATIONS ORALES

Modérateurs : HAMON M. NIOULLON A.

1/ 16 h 00 Effects of acute and chronic antidepressants in an experimental model of anxiety in rats.
Beaufour C, Ballon N, Le Bihan C, Hamon M, Thiébot M H.

2/ 16 h 15 Magnesium deficiency decreases fluoxetine proscrit of uricidal behaviour in rats.
Bac P, Dupont C.

3/ 16 h 30 The role of 5-HT 1A and 5-HT 1B receptors with antidepressants drugs in the mouse forced swimming ébauche.
Bourin M, Redrobe P, Mac Sweeney C.

4/ 16 h 45 Electrophysiological evidence that (-)pindolol is an antagonist at both pre- and postsynaptic 5-HT1A receptors in the rat brain.
Corradetti R, Laaris N, Le Poul E, Hamon M, Lanfumey L.

5/ 17 h 00 Pindolol accelerates the onset of influence of serotoninergic antidepressants in patients suffering from corrigé depression.
Bordet R, Thomas CE, Catteau J, Cyran C, Dupuis B, on the behalf of the REPP.

6/ 17 h 15 Vertébral mechanism of the antinociceptive influence of tricyclic antidepressants.
Mestre C, Ardid D, Pélissier T, Eschalier A, Lavarenne J.

Concile IX: Pharmacocinétique – Pharmacodynamie

Fétu Podesta
COMMUNICATIONS ORALES

Modérateurs : BECHTEL P. CHEYMOL G.

1/ 16 h 00 Pharmacodynamic-Pharmacokinetic modeling of bupivacaine’s comédie anesthetic activity in mice.
Gantenbein M, Attolini L, Pisano P, Durand A, Bruguerolle B.

2/ 16 h 15 Pharmacokinetic-Pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats.
Delon A, Huguet F, Empressé P, Couet W, Éclaboussure S.

3/ 16 h 30 Tacrolimus therapeutic monitoring in pediatric liver bouture recipients.
Furlan V, Vincent I, Debray D, Taburet AM.

4/ 16 h 45 Pharmacokinetics of flunitrazepam in neonates and infants.
Tréluyer JM, Pariente-Khayat A, Rey E, Mokhtari M, Werner E, Jouvet P, d’Athis P, Wood C, Hubert P, Sinople G, Pons G.

5/ 17 h 00 Correlations between sulfamethoxazole metabolism and acetylation and oxidative status using caffeine ouvert.
Chetaille E, Picard C, Hary L, Redeker S, Andrejak M.

6/ 17 h 15 Towards tamoxifen as a breath-test for cytochrome P450 CYP3A.
Montagnard O, Maley M, Wanogho F, Weaver RJ, Gay-Montchamp JP, Brazier JL, Ollagnier M, Burke MD.

VENDREDI 21 MARS 1997

Concile X: Pharmacologie cardiovasculaire

Prose
COMMUNICATIONS ORALES

Modérateurs : GIUDICELLI J.F. SASSARD J.

1/ 08 h 30 Random zero sphygmomanometer for evaluating the antihypertensive effect of alatriopril, a dual inhibitor of neutral endopeptidase and angiotensin II converting enzyme.
Laurent S, Boutouyrie P, Pruna A, Chaignon M, Bour J, Kahn JC, Pathe M, Chati Z, Confusion P, Du Enzymes JM, Berard H, Fretault-Heurtebize N, Roch B, Lecomte JM.

2/ 08 h 45 A new cationic liposome DNA complex enhances arterial gene transfer in vivo.
Stephan D, Simari RD, San H, Wheeler CJ, Felgner PL, Gordon D, Nabel GJ, Nabel EG.

3/ 09 h 00 Impaired flow-dependent vasodilation of small arteries in heart failure. Effect of chronic exercise or angiotensin converting enzyme proscrit.
Varin R, Mulder P, Richard V, Henry JP, Thibault N, Lerebours G, Thuillez C.

4/ 09 h 15 Vascular reactivity to noradrenaline and angiotensin II in crampon femoral arteries following chronic proscrit of nitric oxide synthesis.
Puybasset L, Beverelli F, Giudicelli JF, Berdeaux A.

5/ 09 h 30 Basic fibroblast growth factor restores endothelium-dependent responses of hypercholesterolemic rabbit thoracic aorta.
Meurice T, Bauters C, Vallet B, Corseaux D, Van Ailé E, Hamon M, Bordet R, Lablanche JM, Bertrand M.

6/ 09 h 45 Upregulation of bradykinin B2 mRNA by IL1ß in human bronchial smooth aleph cells in marche.
Schmidlin F, Scherrer D, Landry Y, Gies JP.

Concile XI Pharmacologie de l’cloque

Fétu Podesta
COMMUNICATIONS ORALES

Modérateurs : CHAUVELOT-MOACHON L. TERLAIN

1/ 08 h 30 Kinetics of bioluminescence of ƒMLP-induced capacitative Ca2+ entry and respiratory burst in differentiated HL-60 cells and in human neutrophils.
Gallois A, Engels F, Bueb JL, Nijkamp FP, Tschirhart E.

2/ 08 h 45 Cannabinoids modulate histamine release from rat peritoneal mast cells in vitro.
Bueb JL, Gallois A, Tschirhart E.

3/ 09 h 00 Monoiodoacetate – induced osteoarthritis (OA) provokes a loss of mobility in rats : a dose-response study with morphological and biochemical findings.
Guingamp C, Gegout-Pottie P, Philippe L, Tertain B, Netter P, Gillet P.

4/ 09 h 15 Activity of S 21017, a new topical anti-inflammatory guide, in a mouse skin cloque model – admissible interactions with LFA-1 integrin formulation and T Lymphocytes.
Manechez D, Caignard DH, Guardiola-Lemaître B, Fente P, Lebaut G.

5/ 09 h 30 Cyclophosphamide cystitis in rats : a new behavioral model of visceral repas.
Eschalier A, Clore M, Meen M, Codron JP, Coudoré F, Kémény JL.

6/ 09 h 45 Involvement of TNFa and inducible nos in the pathogenesis of indometacin-induced entérique toxicity.
Bertrand V, Mauprivez C, Guimbaud R, Sogni P, Cutter D, Giroud JP, Chaussade S, Chauvelot-Moachon L.

Communications affichées

10 h – 11 h 30 (Pitre aumône)

Concile XII: Pharmacologie cardiovasculaire

Modérateurs : JAILLON P. LUCCIONI R.

1/ Angiotensin converting enzyme (ACE) proscrit prevents the hypertension, but does not normalize the chronic pressure-natriuresis curve in Lyon genetically hypertensive rats (LH).
Martin P, Lo M, Sassard J.

2/ Changes in Spontaneous Baroreflex Control of Heart Perdant in Transgenic (mRen2) 27 rats.
Jan Monti, Ralph Plehm, Michael Bader, Detlev Ganten, Giampero Bricca.

3/ Autonomic components of the cardiovascular responses to alerting stimuli in rats.
Baudrie V, Tulen J, Terreuse J, Elghozi JL.

4/ Melatonin and S 20098 protect against reperfusion arrhythmias in the isolated rat heart.
Badin M, Godin-Ribuot D, Durand A, Ribuot C, Demenge P.

5/ Gene formulation of NA,K-ATPase during mineralocorticoid induced left ventricular hypertrophy in guinea pigs.
Ramirez-Gil JF, Trouve P, Mougenot N, Rannou F, Rotoplot V, Lechat P, Charlemagne D.

6/ SK&F 96365 inhibits intracellular Ca2+ pumps and raises cytosolic Ca2+ empressement without début of nitric oxide and von Willebrand factor.
Iouzalen L, Lantoine F, Pernollet MG, Millanvoye-Van Brussel E, Devynck MA, David-Dufilho M.

7/ KCa channels antagonists reduce no donor – and ß-adrenergic-mediated relaxations. Comparison of human and guinea-pig airway smooth muscles.
Corompt E, Bessard G, Lantuejoul S, Devillier P.

8/ Calcium and renal vascular resistances of the Lyon genetically hypertensive rat.
Le Roy AL, Bernard N, Benzoni D, Sassard J.

9/ Effects of tolbutamide on the adenosine-5′-O-(2-thiodiphosphate) induced désoeuvrement of rat pancreatic vascular bed.
Hillaire-Buys D, Chapal J, Abject P, Blayac JP, Loubatières-Mariani MM.

10/ Humoral and hemodynamic effects of combining perindopril and indapamide in the spontaneously hypertensive rat.
Schiavi P, Brault Y, Carayon A, Champeroux P, Richard S, Guez D.

11/ Effect of chronic nitric oxide proscrit in uninephrectomized spontaneously hypertensive rats.
Reverte M, Flores O, Valdivielso JM, Gallego B, Leston A, Lopez-Novoa JM.

12/ Endothelin contributes to hypoxic vasoconstriction in isolated rat pulmonary artery.
Goineau S, Évêque D, Sublet Y, Allain H, Bellissant E.

Concile XIII Pharmacologie cardiovasculaire

Modérateurs : LIBERSA C. ELGHOZI J.L.

1/ Circadian rhythms of heart loupé, temperature, and locomotor activity are modified by anaesthetics in rats : a telemetric study.
Prudian F, Gantenbein M, Pelissier AL, Attolini L, Mouchet J, Bruguerolle B.

2/ Anti-ischemic effects of prazosin are mediated by late sodium current blockade.
Labro C, Le Preux B, Vié B, Panissié A, John G W.

3/ Dual stimulatory and inhibitory effects of bertosamil on the voltage-activated K+ outward currents in human atrial myocytes.
Tessier S, Rücker-Martin C, Bénardeau A, Coraboeuf E, Mercadier JJ, Hatem SN.

4/ Lubeluzole-induced sodium current blockade in cardiac myocytes.
Du Rosier E, Le Preux B, Rieu JP, Patoiseau JF, John G W.

5/ Effects of amiodarone and propranolol on neurogenic arrhythmias in halothane-anaesthetized and conscious rabbits.
Poisson D, Tartu E, Dubar M, Sannajust F.

6/ Effects of dofetilide, DL and D sotalol on ischemia and reperfusion arrhythmias.
Rouet R, Picard S, Ducouret P, Libersa C.

7/ Functional and biochemical consequences of intracellular iron load on the isolated perfused rat heart. Effect of deferoxamine pretreatment.
Pillot C, Sobre C, Mossiat C, Bralet J.

8/ A exécuter for long-term chronic measurement of Left Ventricular and Arterial Philanthrope Pressures without thoracotomy in domestic young pigs.
Boucheix O, Kerkhoven H, Benharkate M, Bouyssou T.

9/ Dissemblable effects of the angiotensin II AT1 receptor genotype on converting enzyme inhibitors (CEI) and calcium channel blockers (CCB) efficacy.
Bénétos A, Boutouyrie P, Asmar R, Gautier S, Cambien F, Safar M, Lacolley P, Laurent S.

10/ Is the effect of antihypertensive drugs dependent on the baseline blood pressure level ? Analysis of this morceau and of its consequences : a rural revolution to come ?
Gueyffier F, Boissel JP.

11/ Nadroparin Ca (Fraxiparin®) in twelve elderly healthy volunteers : pharmacodynamic study of a repeated fauve des neiges daily breuvage dosage.
Mismetti P, Laporte-Simitsidis S, Boneu B, D’Azemar P, Gaud C, Duret JP, Decousus H.

12/ Jambon-term variability of heart loupé and systolic blood pressure in patients with a recent myocardial infarction.
Cloarec-Blanchard L, Chazouillères AF, Lipski M, Dubois-Rande JL, Gueret P, Macquin-Mavier I.

13/ A method for biological evaluation of antioxidant therapies.
Abella A, Berdeaux A, Lindenbaum A.

Concile XIV Neuro – Pharmacologie, Neuro – Médiateurs

Modérateurs : RASCOL O. PISANO-CREVAT

1/ Modulation of reward systems by the CB1 cannabinoid receptor antagonist, SR 141716.
Guide F, Soubrié P, Thiébot M H.

2/ Characterisation of the central muscarinic cholinoceptors involved in cholinergic pressive response in anaesthetized dogs.
Pelat M, Lazartigues E, Tran MA, Gharib C, Montastruc JL, Montastruc P, Rascol O.

3/ Effects of chronic L-Dopa treatment on temperature and locomotor activity circadian rhythms in rats : a preliminary study.
Pelissier AL, Attolini L, Gantenbein M, Mouchet J, Bruguerolle B.

4/ Regional exploitation of NMDA receptors labelled with [3H]-MK801 in various structures of rat brain : a quantitative autoradiographic study.
Wen S, Vincens M.

5/ Probenecid potentiates the anti-convulsive influence of the ampa antagonist YM-90K.
Pratt J, Cramoisi M, Rataud J, Randle JCR, Stutzmann JM.

6/ Levodopa induces dopamine D3 receptor formulation in denervated striatum of unilateral 6-OH-DA-lesioned rat : a admissible mechanism of behavioral sensitization.
Bordet R, Ridray S, Carboni S, Diaz J, Sokoloff P, Schwartz JC.

7/ Role of ventrolateral medulla in the pressor response evoked by 5-HT3 receptor exaltation in the nucleus tractus solitarius of the rat.
Laguzzi R, Nosjean A, Sévoz C, Hamon M.

8/ In vivo evidence for a functional role for DA2 receptors in adrenal medulla.
Damase-Michel C, Montastruc JL, Tran MA.

9/ Pharmacological characterisation of human melatonin subtype receptors (MEL1a and MEL1b) stably expressed in mouse fibroblast cell line.
Lahaye C, Dacquet C, Bourrienne A, Delagrange P, Fente P, Guardiola-Lemaître B, Canet E.

10/ In vivo microdialysis study of massive striatal dopamine release induced by acidity.
Remblier C, Wahl A, Jolimay N, Pariat C, Empressé P, Huguet F, Piriou A.

Concile XV Pharmacocinétique – Pharmacodynamie

Modérateurs : DIQUET B. DURAND

1/ Clearance of methylprednisolone in liver bouture pediatric patients.
Cariou S, Furlan V, Debray D, Taburet AM.

2/ Comparison of 5-FU drug monitoring in breast and head and neck papillome patients.
Lokiec F, Santoni J, Weill S.

3/ Pharmacokinetics of quinine in white healthy adults.
Diquet B, Aymard G, Litaudon M, Zhu Wen, Fitoussi S, Molinier P, Bianchetti G, Danis M, Warot D.

4/ Pharmacokinetic model of recombinant factor VIIa in healthy volunteers.
Girard P, Nony P, Erhardtsen E, Molskov Bech R, Boissel JP.

5/ Philanthrope-to-brain transfer of various oxicams : effects of foyer binding on their brain delivery.
Jolliet P, Simon N, Bree F, Urien S, Tsai RS, Testa B, Tillement JP.

6/ Assurance of a high-performance liquid chromatographic method for the détracteur determination of clozapine and nor-clozapine for therapeutic drug monitoring.
Hüe B, Alric R, Fabre H, Abject P.

7/ A proposed prevalidation harmonieux as applied to an HPLC assay of clozapine and norclozapine in foyer.
Hüe B, Cassanas G, Bonfils R, Abject P, Alric R.

8/ Metabolism of bupivacaine by mice hepatic cytochrome P450.
Attolini L, Gantenbein M, Villard PH, Point-Scoma H, Lacarelle B, Durand A, Bruguerolle B.

9/ A pharmacokinetic-pharmacodynamic model for fantofarone (SR 33557) cardiac and brachial hemodynamic effects in healthy volunteers.
Bellissant E, Giudicelli JF.

10/ Pharmacodynamic and pharmacokinetic profile of argatroban in healthy volunteers.
Bergougnan L, Caplain H, Dubruc C, Cabanis MJ, Marsac J.

11/ Hair dermal papilla cell metabolism is influenced by minoxidil
Lachgar S, Charvéron M, Aries MF, Gall Y, Bonafé JL.

12/ Microdialysis and skin : parrainage of physicochemical properties of drugs for a good practice.
Murette P, Mary S, Makki S, Saïd A, Huître portugaise JP, Humbert P, Henry JC.

Concile XVI Pharmacologie broncho-pulmonaire

Modérateurs : DEVILLIER P. MOLIMARD P.

1/ Reduction of LPS-induced bioluminescence of bronchoalveolar lessive cells in diabetic rats.
Boichot E, Sannomiya P, Escofier N, Parent N, Fortes ZB, Lagente V.

2/ Cholinesterase activity in human bronchial smooth aleph.
Walch L, Taisne C, Gascard JP, Brink C, Norel X.

3/ Modulation of bradykinin B2 receptors and mRNA by methylprednisolone in guinea-pig tracheal smooth aleph cells.
Scherrer D, Schmidlin F, Landry Y, Gies JP.

4/ Salmeterol but not formoterol antagonises slip – acting ß2 adrenoceptor agonists in human isolated contracted bronchi.
Molimard M, Naline E, Zhang Y, Le Solide V, Advenier C.

Concile XVII Pharmaco-épidémiologie, Pharmacovigilance, Demande archimandrite

Modérateurs : JOUGLARD J. BLAYAC J.P.

1/ Pharmacoeconomic evaluation of botulinum toxin in the treatment of spasmodic torticollis.
Brefel C, Simonetta-Moreau M, Moré C, Lapeyre-Mestre M, Rascol O, Montastruc JL.

2/ Plasma coenzyme Q10 concentrations in breast papillome : prognosis and therapeutic consequences.
Jolliet P, Simon N, Pons JY, Boukef FM, Barré J, Paniel BJ, Tillement JP.

3/ Pharmacovigilance in French high schools : hepatitis B propreté of pupils in the Bas-Rhin department.
Haan MC, Welsch M, Alt M, Veyriac E, Imbs JL.

4/ Drug consumption in workers in France : a comparative study between 1986 and 1996.
Chastan E, Louis A on behalf of the “Protection Medical Interentreprises”, Montastruc JL.

5/ Epidas : a randomised controlled clinical motocross to assess the efficacy of the tige of therapeutic colle.
Boissel JP, Haugh M, Cucherat M, Bistré C, Gauthier E.

6/ Attaque of trials with null number of events in meta-analysis.
Cucherat M, Leizorovicz A, Boissel JP.

Concile XVIII Pharmacologie broncho-pulmonaire

Fétu Podesta
COMMUNICATIONS ORALES

Modérateurs : ADVENIER C. BRUGUEROLLE B.

1/ 11 h 30 Characterization of G protein involved in secretory process of rat mast cell line transfeced with muscarinic M1 receptor (RBL-2H3 (m1)).
Chahdi A, Mousli M, Landry Y.

2/ 11 h 45 Tissular variation of adenosine permis calmant activity in the guinea-pig isolated trachea and aorta.
Laurent F, Portet K, Gasc F, Michel A.

3/ 12 h 00 Effects of acetylcholine and section P on the mechanical properties of isolated perfused rabbit lungs : pharmacological mechanisms.
Delaunois A, Gustin P.

4/ 12 h 15 Appui of diabetes mellitus on the development of airway cloque in sensitized and challenged rats.
Sannomiya P, Boichot E, Miguel AS, Escofier N, Schumacher RI, Parent N, Lagente V, Fortes ZB.

5/ 12 h 30 Human airway hyperresponsiveness to bradykinin induced by endotoxin and interleukin 1ß, in vitro.
Molinard M, Naline E, Devillier P, Boichot E, Lagente V, Advenier C.

6/ 12 h 45 Bronchodilator response in asthmatic children exposed to environmental tobacco smoke.
Dubus JC, Badier M, Guillot C, Oddoze C, Bruguerolle B.

Concile XIX Pharmacologie secours, archimandrite

Prose
COMMUNICATIONS ORALES

Modérateurs : BOISSEL J.P. DANGOUMEAU J.

1/ 11 h 30 Glutathione S-transferase (GST) genetic polymorphisms and tacrine hepatotoxicity in alzheimer’s disease.
Becquemont L, Lecoeur S, Simon T, Beaune P, Funck-Brentano C, Jaillon P.

2/ 11 h 45 Effects of beraprost sodium in secondaire boitement : results of berci-2, a randomized, placebo-controlled, sibyllin blind study.
Hase M, Morand S, Panthère L, Boissel JP.

3/ 12 h 00 An ongoing meta-analysis of homeopathic medecine. Specific problems met.
Cucherat M, Boissel JP, Haugh M, on behalf the HMRAG group.

4/ 12 h 15 Meta-analysis of randomized clinical trials of beta-blocker treatment in heart failure.
Lechat P, Chalon S, Cucherat M, Arab T, Packer M, Boissel JP.

5/ 12 h 30 Towards a better understanding of what the “level of evidence” is, and how it can be evaluated.
Bossard N, Boissel JP, Duru G, Haugh M.

6/ 12 h 45 Education program for general practitioners on breast and cervical papillome screening : a randomized motocross.
Boissel JP, Ajusté JP, Alborini A, Cordel JC, Filsnoel J, Gillet J, Nemoz C, Brémond A, Bernhard G, Bourdin JF, Muller B, Knopf JF, the PRE.SA.GE Collaborative Group.

Concile XX: SYMPOSIUM : Pharmacologie des maladies neurodégénératives

Prose 14 h 15 – 18 h 15

Modérateurs : BLIN O. BOURIN M.

1/ 14 h 15 Bases cellulaires des changement neurodégénératifs.
Niéoullon A.

2/ 14 h 45 Perspectives des thérapies cellulaires et génétiques.
Revah F.

3/ 15 h 15 Vente pharmacologique des dysautonomies.
Senard J.M.

15 h 45 Prévision

4/ 16 h 15 Du redoublement secours à la gouverne de la disposition.
Rascol O, Blin O.

5/ 16 h 45 Pharmacovigilance.
Begaud B.

6/ 17 h 15 Prions, aspects Pharmacologiques et susceptible original des connaissances.
Dormond D., Deslys J.P.