Programme Marseille 1997

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1ère réunion de la Société Française de Pharmacologie

JEUDI 20 MARS 1997

Session I: SYMPOSIUM : Pharmacologie du cartilage

Amphithéâtre 09 h 00 – 13 h 00

Modérateurs : NETTER P., QUENEAU R.

1/ 09 h 00 Présentation du sujet. Netter P. 2/ 09 h 10 Enzymes du Cartilage. Manicourt D.

3/ 09 h 40 IL-1ß et Cartilage articulaire. Jouzeau J.Y.

10 h 10 Pause

4/ 10 h 30 Thérapie biologique et génique de l’arthrose. Pelletier J.P. 5/ 11 h 00 Y-a-t’il des antiarthrosiques de fond chondroprotecteurs ? Lequesne M. 6/ 11 h 30 Les effets indésirables des médicaments sur le cartilage. Bertin P.

7/ 12 h 00 Données récentes sur l’hormonothérapie de la ménopause. Rozenbaum H.

Communications affichées

14 h 30 – 16 h (Présentateur présent)

Session II: Neuro – Pharmacologie expérimentale

Modérateurs : ALLAIN H, THIEBOT M.H.

1/ Angiotensinogen gene expression inhibition with triple helix forming oligonucleotides in brain of transgenic (mRen2) 27 and sprague Dawley control rats unravels the modulatory role of brain angiotensins in cardiovascular regulation.
Bricca G, Voss A, Holger Hof, Wolgang Sommer, Martina Schinke, Manfred Böhm, Michael Bader, Detlev Ganten.

2/ Transient focal cerebral ischaemia and no-synthase activities in mice.
Grandati M, Verrecchia C, Allix M, Boulu R, Plotkine M.

3/ Idazoxan prevents hypoxia-induced injury of rat cerebral cortical astrocytes and neurons in vitro.
Poisson D, Garrigue M A, Muh J P, Sannajust F.

4/ Corticotropin-releasing factor receptors type 1 (CRF1) in human 10 neuroblastoma SH-SY5Y cells.
Schoeffter P, Feuerbach D, Bobirnac I.

5/ Tyrosine kinase inhibitors and cycloheximide antagonize the survival promoting effect of lithium cultured cerebellar granule neurons.
Grignon S, Couraud F, Bruguerolle B.

6/ Tobacco smoke intoxication induced modifications of heart rate, body temperature and locomotor activity in rats.
Pelissier AL, Attolini L, Gantenbein M, Prudian F, Mouchet J, Bruguerolle B.

7/ Ketamine effects on bupivacaine local anaesthetic activity and pharmacokinetics in mice.
Abat C, Gantenbein M, Attolini L, Emperaire N, Bruguerolle B.

8/ Of1 aged mice : decrease in the level of learning / memory.
Carrié I, Monier C, Bourre JM, Francès H.

9/ Effects of hypoxia and cerebral ischemia on HSP72 mRNA expression and protein synthesis in gerbils.
Bertrand N, Flamand B, Borderieux N, Beley A.

Session III: Pharmacologie de la douleur

Modérateurs : ESCHALIER A., CROS G.

1/ Automated analysis of the formalin test, a largely used pain test.
Jourdan D, Ardid D, Bardin M, Dubray C, Neuzeret D, Lamphoutacou L, Eschalier A.

2/ Evidence for the involvement of tachykinins, excitatory amino acids, and neuropeptide FF in two animal models of neurogenic pain.
Coudoré MA, Courteix C, Eschalier A, Zajac JM, Wilcox GL, Fialip J.

3/ Serotonin 5HT3 receptors are not involved in the antinociceptive effect of both serotonin and paracetamol assessed by the formalin test.
Dubray C, Bardin L, Jourdan D, Alloui A, Lavarenne J, Eschalier A.

4/ The effects of social isolation on pain threshold and on different effects of morphine.
Coudereau JP, Monier C, Bourre JM, Francès H.

5/ Neuropeptide FF control of opioid functions in morphine-tolerant mice.
Gelot A, Francés B, Desprat C, Latapie JP, Roussin A, Zajac JM.

6/ Involvement of the spinal serotoninergic system on the function of spinal dopaminergic pathways.
Robein-Dobremez MJ, Durand A, Riachi K, Demenge P.

7/ Alterations of the neuronal activities in the cortical MAP of the PAD vibrissae in rats with a trigeminal neuropathy induced by constriction of one infra-orbital nerve.
Benoist JM, Gautron M, Guilbaud G.

8/ Effects of the analgesic drug up 26-91 on the in vivo release of substance P and calcitonin gene-related peptide from the rat spinal cord.
Ballet S, Mauborgne A, Bourgoin S, Caussade F, Cloarec A, Hamon M, Cesselin F, Collin E.

9/ Extracellular concentrations of met-enkephalin and cholecystokinin in the nucleus accumbens of freely moving rats following analgesic or algic treatments.
Lapeyre S, Mauborgne A, Becker C, Benoliel JJ, Cesselin F, Hamon M, Bourgoin S.

Session IV: Neuro – Psychopharmacologie clinique


1/ L-Dopa-induced dyskinesias improvement by an a2 antagonist, idazoxan, in patients with Parkinson’s disease.
Rascol O, Arnulf I, Brefel C, Vidailhet M, Thalamas C, Bonnet AM, Descombes S, Bejjani B, Montastruc JL, Peyro-Saint Paul H, Agid Y.

2/ Selegiline effectiveness in de novo idiopathic Parkinsonian patients.
Simon N, Jolliet P, Cesaro P, Tillement JP.

3/ Differential effects of sleep deprivation and of lorazepam administration on saccadic eye movements in healthy volunteers.
Soubrouillard C, Brefel C, Martineu C, Mestre D, Rascol O, Bruguerolle B, Blin O.

4/ Effects of serotoninergic molecules on processing stages of information in healthy volunteers.
Rihet P, Hasbroucq T, Possamaï C, Bruguerolle B, Blin O.

5/ Performance and memory in healthy young volunteers.
Jacquet A, Callamand S, Habib M, Pisano P, Blin O.

6/ Effects of anxiety on performance, vigilance and emotional reactivity, in healthy volunteers.
Garcia C, Philippot P, Jouve E, Bruguerolle B, Blin O.

Session V: Pharmacologie cardiovasculaire


1/ Influence of vanadyl sulphate (VOSO4) treatment on smooth muscle contractility : Desensitization to VOSO4-induced contraction.
Krosniak M, Cadène A, Bali JP, Serrano JJ, Michel A, Magous R, Teissèdre PL, Soulie ML, Cros G.

2/ Extrahypothalamic synthesis of vasopressin : expression of vasopressin gene in blood vessels from normal or insipidus diabetic brattleboro rats.
Mécnaly I, Serrano JJ, Cros G.

3/ Effects of isradipine on carotid distensibility and blood pressure variability in spontaneously hypertensive rats.
Lacoley P, Challande P, Roche A, Glaser E, Bezie Y, Lucet B, Safar M, Laurent S.

4/ Role of nitric oxide (NO) in the regulation of pulmonary vascular tone in the anesthetized open chest rat.
Valentin JP, Maffre M, John G W.

5/ Effects of estradiol on middle cerebral artery of dietary hypercholesterolemic rabbit.
Oudart N, Javellaud J, Cantini C, Ea-Kim L.

6/ Preconditioning prevents neutrophil adhesion and expression of ICAM-1 after anoxia and reoxygenation in cultured endothelial cells.
Beauchamp P, Richard V, Tamion F, Devaux B, Daveau M, Vaudry H, Lebreton JP, Thuillez C.

7/ Alpha-2 adrenergic / imidazoline receptor ligands induce a paradoxical relaxation of isolated rat peripheral arteries.
Artigues C, Richard V, Varin R, Mulder P, Thuillez C.

8/ Distal skin heating, a new method to study the flow-dependent vasodilatation of peripheral conduit arteries in human.
Benoist A, Joannidès R, Bakkali El H, Compagnon P, Lahary A, Richard V, Thuillez C.

Session VI Pharmacologie cardiovasculaire

Modérateurs : BERDEAUX A. LAURENT S.

1/ Inhibition by furosemide of the TXA2-induced contraction of human internal mammary artery and saphenous vein in vitro.
Stanke F, Cracowski JL, Magne JL, Chavanon O, Bessard G, Devillier P.

2/ Dobutamine and enoximone-induced relaxations on human internal mammary and gastroepiploic arteries depend on contracting agents : a possible thromboxane A2-related functional antagonism ?
Cracowski JL, Stanke F, Chavanon O, Blin D, Mallion JM, Bessard G, Devillier P.

3/ In vitro renal vascular response to vasopressin – modulation by endothelial nitric oxide.
Barthelmebs M, Krieger JP, Grima M, Nisato D, Imbs JL.

4/ Renin, angiotensin converting enzyme and angiotensins I and II variations in the Kidney after salt-depletion and uninephrectomy.
Busso C, Grima M, Michel B, Barthelmebs M, Imbs JL.

5/ Influence of authentic nitric oxide on basal cytosolic [Ca2+] and Ca2+ release from internal stores in human platelets.
Le Quan Sang KH, Lantoine F, Devynck MA.

6/ Local delivery of low molecular weight heparin fails to prevent restenosis in a hypercholesterolemic rabbit model.
Vuillemenot A, Kantelip B, Kantelip JP, Cai Xu, Bassand JP.

7/ Differential expression of cardiac VEGF mRNA in hypoxic and monocrotaline-induced pulmonary hypertension.
Partovian C, Ladoux A, Eddahibi S, Adnot S, Frelin C.

8/ Role of epoxyeicosatrienoic acids in renal alterations of the Lyon genetically hypertensive rat.
Messer I, Bernard N, Benzoni D, Sassard J.

9/ Endothelium and nitric oxide dependence of ß-adrenergic relaxation in guinea pig aorta.
Jondet A, Gogny M, Blin M, Vu AT, Bidon JC.

10/ Pharmacological profile of a new imidazolinic ligand : S 22687.
Rettori MC, Porsolt R, Nutt D, Lalies M, Guardiola-Lemaître B.

11/ A direct and indirect cytoprotective effect of a new antioxidant against the toxicity of oxidised LDL on cultured endothelial cells.
Nègre-Salvayre A, Bizot-Espiard JG, Guardiola-Lemaître B, Caignard DH, Lesieur D, Salvayre R.

12/ Ciclosporin effects on “in vitro” oxidizability of L.D.L. isolated from rabbit plasma.
Barthélémy M, Chomard P, Mounié J, Artur Y, Escousse A, Mousson C.

Session VII Pharmacologie de l’inflammation

Modérateurs : BOUVENOT G. ROUVEIX B.

1/ Relations between functional, inflammatory and degenerative parameters during adjuvant arthritis (AA).
Philippe L, Gegout-Pottie P, Guingamp C, Bordji K, Terlain B, Netter P, Gillet P.

2/ In vitro effect of cefepime on the production of superoxide anion by human polymorphonuclear neutrophils.
Moutard I, Gressier B, Brunet C, Dine T, Luyckx M, Ballester L, Cazin M, Cazin JC, With the technical assistance of S. Battez-Lebegue.

3/ Effect of naftazone (Etioven®) on proinflammatory factors produced by endothelial cells in hypoxic conditions.
Fortier M, Le Toulouse M, Bach S, Rambourg G, Bloy C.

4/ Zinc oxide and titane oxide activity on UVA/UVB induced- interleukine -production by epidermal cell line.
Aries MF, Vaissière C, Charvéron M, Gall Y.

5/ Up-regulation of tissular TNFa in inflammatory rats by NSAID : potential therapeutic and toxicological implication.
Mauprivez C, Bertrand V, Guimbaud R, Chen YL, Sogni P, Couturier D, Giroud JP, Chaussade S, Chauvelot-Moachon L.

6/ Effect of food and tobacco on lactulose and rhamnose intestinal permeability in healthy volunteers.
Le Gall R, Heresbach D, Bentué-Ferrer D, Mourot J, Allain H, Bretagne JF, Gosselin M.

7/ Inter- and intraindividual variability of gastric emptying estimated by paracetamol pharmacokinetics in healthy subjects.
Paintaud G, Thibault P, Queneau PE, Magnette J, Bechtel PR.

8/ The imidazoline antazoline stimulates insulin secretion and improves glucose tolerance in rats and dogs.
Bertrand G, Berdeu D, Ribes G, Puech R, Loubatières-Mariani MM.

9/ Comparative effects of ATP and related analogues on insulin secretion from the rat pancreas. Structure-activity relationship.
Chapal J, Bertrand G, Hillaire-Buys D, Petit P, Loubatières-Mariani MM.

Session VIII: Neuro – Pharmacologie


Modérateurs : HAMON M. NIOULLON A.

1/ 16 h 00 Effects of acute and chronic antidepressants in an experimental model of anxiety in rats.
Beaufour C, Ballon N, Le Bihan C, Hamon M, Thiébot M H.

2/ 16 h 15 Magnesium deficiency decreases fluoxetine inhibition of uricidal behaviour in rats.
Bac P, Dupont C.

3/ 16 h 30 The role of 5-HT 1A and 5-HT 1B receptors with antidepressants drugs in the mouse forced swimming test.
Bourin M, Redrobe P, Mac Sweeney C.

4/ 16 h 45 Electrophysiological evidence that (-)pindolol is an antagonist at both pre- and postsynaptic 5-HT1A receptors in the rat brain.
Corradetti R, Laaris N, Le Poul E, Hamon M, Lanfumey L.

5/ 17 h 00 Pindolol accelerates the onset of action of serotoninergic antidepressants in patients suffering from major depression.
Bordet R, Thomas CE, Catteau J, Cyran C, Dupuis B, on the behalf of the REPP.

6/ 17 h 15 Spinal mechanism of the antinociceptive action of tricyclic antidepressants.
Mestre C, Ardid D, Pélissier T, Eschalier A, Lavarenne J.

Session IX: Pharmacocinétique – Pharmacodynamie

Salle Podesta

Modérateurs : BECHTEL P. CHEYMOL G.

1/ 16 h 00 Pharmacodynamic-Pharmacokinetic modeling of bupivacaine’s local anesthetic activity in mice.
Gantenbein M, Attolini L, Pisano P, Durand A, Bruguerolle B.

2/ 16 h 15 Pharmacokinetic-Pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats.
Delon A, Huguet F, Courtois P, Couet W, Bouquet S.

3/ 16 h 30 Tacrolimus therapeutic monitoring in pediatric liver transplant recipients.
Furlan V, Vincent I, Debray D, Taburet AM.

4/ 16 h 45 Pharmacokinetics of flunitrazepam in neonates and infants.
Tréluyer JM, Pariente-Khayat A, Rey E, Mokhtari M, Werner E, Jouvet P, d’Athis P, Wood C, Hubert P, Olive G, Pons G.

5/ 17 h 00 Correlations between sulfamethoxazole metabolism and acetylation and oxidative status using caffeine probe.
Chetaille E, Picard C, Hary L, Redeker S, Andrejak M.

6/ 17 h 15 Towards tamoxifen as a breath-test for cytochrome P450 CYP3A.
Merle O, Maley M, Wanogho F, Weaver RJ, Gay-Montchamp JP, Brazier JL, Ollagnier M, Burke MD.


Session X: Pharmacologie cardiovasculaire



1/ 08 h 30 Random zero sphygmomanometer for evaluating the antihypertensive effect of alatriopril, a dual inhibitor of neutral endopeptidase and angiotensin II converting enzyme.
Laurent S, Boutouyrie P, Pruna A, Chaignon M, Bour J, Kahn JC, Pathe M, Chati Z, Bataille P, Du Enzymes JM, Berard H, Fretault-Heurtebize N, Roch B, Lecomte JM.

2/ 08 h 45 A new cationic liposome DNA complex enhances arterial gene transfer in vivo.
Stephan D, Simari RD, San H, Wheeler CJ, Felgner PL, Gordon D, Nabel GJ, Nabel EG.

3/ 09 h 00 Impaired flow-dependent vasodilation of small arteries in heart failure. Effect of chronic exercise or angiotensin converting enzyme inhibition.
Varin R, Mulder P, Richard V, Henry JP, Thibault N, Lerebours G, Thuillez C.

4/ 09 h 15 Vascular reactivity to noradrenaline and angiotensin II in canine femoral arteries following chronic inhibition of nitric oxide synthesis.
Puybasset L, Beverelli F, Giudicelli JF, Berdeaux A.

5/ 09 h 30 Basic fibroblast growth factor restores endothelium-dependent responses of hypercholesterolemic rabbit thoracic aorta.
Meurice T, Bauters C, Vallet B, Corseaux D, Van Belle E, Hamon M, Bordet R, Lablanche JM, Bertrand M.

6/ 09 h 45 Upregulation of bradykinin B2 mRNA by IL1ß in human bronchial smooth muscle cells in culture.
Schmidlin F, Scherrer D, Landry Y, Gies JP.

Session XI Pharmacologie de l’inflammation

Salle Podesta


1/ 08 h 30 Kinetics of activation of ƒMLP-induced capacitative Ca2+ entry and respiratory burst in differentiated HL-60 cells and in human neutrophils.
Gallois A, Engels F, Bueb JL, Nijkamp FP, Tschirhart E.

2/ 08 h 45 Cannabinoids modulate histamine release from rat peritoneal mast cells in vitro.
Bueb JL, Gallois A, Tschirhart E.

3/ 09 h 00 Monoiodoacetate – induced osteoarthritis (OA) provokes a loss of mobility in rats : a dose-response study with morphological and biochemical findings.
Guingamp C, Gegout-Pottie P, Philippe L, Tertain B, Netter P, Gillet P.

4/ 09 h 15 Activity of S 21017, a new topical anti-inflammatory agent, in a mouse skin inflammation model – possible interactions with LFA-1 integrin expression and T Lymphocytes.
Manechez D, Caignard DH, Guardiola-Lemaître B, Renard P, Lebaut G.

5/ 09 h 30 Cyclophosphamide cystitis in rats : a new behavioral model of visceral pain.
Eschalier A, Boucher M, Meen M, Codron JP, Coudoré F, Kémény JL.

6/ 09 h 45 Involvement of TNFa and inducible nos in the pathogenesis of indometacin-induced intestinal toxicity.
Bertrand V, Mauprivez C, Guimbaud R, Sogni P, Couturier D, Giroud JP, Chaussade S, Chauvelot-Moachon L.

Communications affichées

10 h – 11 h 30 (Présentateur présent)

Session XII: Pharmacologie cardiovasculaire

Modérateurs : JAILLON P. LUCCIONI R.

1/ Angiotensin converting enzyme (ACE) inhibition prevents the hypertension, but does not normalize the chronic pressure-natriuresis curve in Lyon genetically hypertensive rats (LH).
Martin P, Lo M, Sassard J.

2/ Changes in Spontaneous Baroreflex Control of Heart Rate in Transgenic (mRen2) 27 rats.
Jan Monti, Ralph Plehm, Michael Bader, Detlev Ganten, Giampero Bricca.

3/ Autonomic components of the cardiovascular responses to alerting stimuli in rats.
Baudrie V, Tulen J, Blanc J, Elghozi JL.

4/ Melatonin and S 20098 protect against reperfusion arrhythmias in the isolated rat heart.
Joyeux M, Godin-Ribuot D, Durand A, Ribuot C, Demenge P.

5/ Gene expression of NA,K-ATPase during mineralocorticoid induced left ventricular hypertrophy in guinea pigs.
Ramirez-Gil JF, Trouve P, Mougenot N, Rannou F, Robert V, Lechat P, Charlemagne D.

6/ SK&F 96365 inhibits intracellular Ca2+ pumps and raises cytosolic Ca2+ concentration without production of nitric oxide and von Willebrand factor.
Iouzalen L, Lantoine F, Pernollet MG, Millanvoye-Van Brussel E, Devynck MA, David-Dufilho M.

7/ KCa channels antagonists reduce no donor – and ß-adrenergic-mediated relaxations. Comparison of human and guinea-pig airway smooth muscles.
Corompt E, Bessard G, Lantuejoul S, Devillier P.

8/ Calcium and renal vascular resistances of the Lyon genetically hypertensive rat.
Le Roy AL, Bernard N, Benzoni D, Sassard J.

9/ Effects of tolbutamide on the adenosine-5′-O-(2-thiodiphosphate) induced relaxation of rat pancreatic vascular bed.
Hillaire-Buys D, Chapal J, Petit P, Blayac JP, Loubatières-Mariani MM.

10/ Humoral and hemodynamic effects of combining perindopril and indapamide in the spontaneously hypertensive rat.
Schiavi P, Brault Y, Carayon A, Champeroux P, Richard S, Guez D.

11/ Effect of chronic nitric oxide inhibition in uninephrectomized spontaneously hypertensive rats.
Reverte M, Flores O, Valdivielso JM, Gallego B, Leston A, Lopez-Novoa JM.

12/ Endothelin contributes to hypoxic vasoconstriction in isolated rat pulmonary artery.
Goineau S, Pape D, Sublet Y, Allain H, Bellissant E.

Session XIII Pharmacologie cardiovasculaire

Modérateurs : LIBERSA C. ELGHOZI J.L.

1/ Circadian rhythms of heart rate, temperature, and locomotor activity are modified by anaesthetics in rats : a telemetric study.
Prudian F, Gantenbein M, Pelissier AL, Attolini L, Mouchet J, Bruguerolle B.

2/ Anti-ischemic effects of prazosin are mediated by late sodium current blockade.
Labro C, Le Grand B, Vié B, Panissié A, John G W.

3/ Dual stimulatory and inhibitory effects of bertosamil on the voltage-activated K+ outward currents in human atrial myocytes.
Tessier S, Rücker-Martin C, Bénardeau A, Coraboeuf E, Mercadier JJ, Hatem SN.

4/ Lubeluzole-induced sodium current blockade in cardiac myocytes.
Du Rosier E, Le Grand B, Rieu JP, Patoiseau JF, John G W.

5/ Effects of amiodarone and propranolol on neurogenic arrhythmias in halothane-anaesthetized and conscious rabbits.
Poisson D, Tartu E, Dubar M, Sannajust F.

6/ Effects of dofetilide, DL and D sotalol on ischemia and reperfusion arrhythmias.
Rouet R, Picard S, Ducouret P, Libersa C.

7/ Functional and biochemical consequences of intracellular iron load on the isolated perfused rat heart. Effect of deferoxamine pretreatment.
Pillot C, Marie C, Mossiat C, Bralet J.

8/ A technique for long-term chronic measurement of Left Ventricular and Arterial Blood Pressures without thoracotomy in domestic young pigs.
Boucheix O, Kerkhoven H, Benharkate M, Bouyssou T.

9/ Opposite effects of the angiotensin II AT1 receptor genotype on converting enzyme inhibitors (CEI) and calcium channel blockers (CCB) efficacy.
Bénétos A, Boutouyrie P, Asmar R, Gautier S, Cambien F, Safar M, Lacolley P, Laurent S.

10/ Is the effect of antihypertensive drugs dependent on the baseline blood pressure level ? Analysis of this issue and of its consequences : a cultural revolution to come ?
Gueyffier F, Boissel JP.

11/ Nadroparin Ca (Fraxiparin®) in twelve elderly healthy volunteers : pharmacodynamic study of a repeated once daily curative dosage.
Mismetti P, Laporte-Simitsidis S, Boneu B, D’Azemar P, Gaud C, Duret JP, Decousus H.

12/ Short-term variability of heart rate and systolic blood pressure in patients with a recent myocardial infarction.
Cloarec-Blanchard L, Chazouillères AF, Lipski M, Dubois-Rande JL, Gueret P, Macquin-Mavier I.

13/ A method for biological evaluation of antioxidant therapies.
Abella A, Berdeaux A, Lindenbaum A.

Session XIV Neuro – Pharmacologie, Neuro – Médiateurs


1/ Modulation of reward systems by the CB1 cannabinoid receptor antagonist, SR 141716.
Chaperon F, Soubrié P, Thiébot M H.

2/ Characterisation of the central muscarinic cholinoceptors involved in cholinergic pressive response in anaesthetized dogs.
Pelat M, Lazartigues E, Tran MA, Gharib C, Montastruc JL, Montastruc P, Rascol O.

3/ Effects of chronic L-Dopa treatment on temperature and locomotor activity circadian rhythms in rats : a preliminary study.
Pelissier AL, Attolini L, Gantenbein M, Mouchet J, Bruguerolle B.

4/ Regional distribution of NMDA receptors labelled with [3H]-MK801 in various structures of rat brain : a quantitative autoradiographic study.
Wen S, Vincens M.

5/ Probenecid potentiates the anti-convulsive action of the ampa antagonist YM-90K.
Pratt J, Roux M, Rataud J, Randle JCR, Stutzmann JM.

6/ Levodopa induces dopamine D3 receptor expression in denervated striatum of unilateral 6-OH-DA-lesioned rat : a possible mechanism of behavioral sensitization.
Bordet R, Ridray S, Carboni S, Diaz J, Sokoloff P, Schwartz JC.

7/ Role of ventrolateral medulla in the pressor response evoked by 5-HT3 receptor stimulation in the nucleus tractus solitarius of the rat.
Laguzzi R, Nosjean A, Sévoz C, Hamon M.

8/ In vivo evidence for a functional role for DA2 receptors in adrenal medulla.
Damase-Michel C, Montastruc JL, Tran MA.

9/ Pharmacological characterisation of human melatonin subtype receptors (MEL1a and MEL1b) stably expressed in mouse fibroblast cell line.
Lahaye C, Dacquet C, Bourrienne A, Delagrange P, Renard P, Guardiola-Lemaître B, Canet E.

10/ In vivo microdialysis study of massive striatal dopamine release induced by acidity.
Remblier C, Wahl A, Jolimay N, Pariat C, Courtois P, Huguet F, Piriou A.

Session XV Pharmacocinétique – Pharmacodynamie

Modérateurs : DIQUET B. DURAND

1/ Clearance of methylprednisolone in liver transplant pediatric patients.
Cariou S, Furlan V, Debray D, Taburet AM.

2/ Comparison of 5-FU drug monitoring in breast and head and neck cancer patients.
Lokiec F, Santoni J, Weill S.

3/ Pharmacokinetics of quinine in white healthy adults.
Diquet B, Aymard G, Litaudon M, Zhu Wen, Fitoussi S, Molinier P, Bianchetti G, Danis M, Warot D.

4/ Pharmacokinetic model of recombinant factor VIIa in healthy volunteers.
Girard P, Nony P, Erhardtsen E, Molskov Bech R, Boissel JP.

5/ Blood-to-brain transfer of various oxicams : effects of plasma binding on their brain delivery.
Jolliet P, Simon N, Bree F, Urien S, Tsai RS, Testa B, Tillement JP.

6/ Validation of a high-performance liquid chromatographic method for the concurrent determination of clozapine and nor-clozapine for therapeutic drug monitoring.
Hüe B, Alric R, Fabre H, Petit P.

7/ A proposed prevalidation design as applied to an HPLC assay of clozapine and norclozapine in plasma.
Hüe B, Cassanas G, Bonfils R, Petit P, Alric R.

8/ Metabolism of bupivacaine by mice hepatic cytochrome P450.
Attolini L, Gantenbein M, Villard PH, Point-Scoma H, Lacarelle B, Durand A, Bruguerolle B.

9/ A pharmacokinetic-pharmacodynamic model for fantofarone (SR 33557) cardiac and brachial hemodynamic effects in healthy volunteers.
Bellissant E, Giudicelli JF.

10/ Pharmacodynamic and pharmacokinetic profile of argatroban in healthy volunteers.
Bergougnan L, Caplain H, Dubruc C, Cabanis MJ, Marsac J.

11/ Hair dermal papilla cell metabolism is influenced by minoxidil
Lachgar S, Charvéron M, Aries MF, Gall Y, Bonafé JL.

12/ Microdialysis and skin : influence of physicochemical properties of drugs for a good practice.
Muret P, Mary S, Makki S, Saïd A, Belon JP, Humbert P, Henry JC.

Session XVI Pharmacologie broncho-pulmonaire


1/ Reduction of LPS-induced activation of bronchoalveolar lavage cells in diabetic rats.
Boichot E, Sannomiya P, Escofier N, Germain N, Fortes ZB, Lagente V.

2/ Cholinesterase activity in human bronchial smooth muscle.
Walch L, Taisne C, Gascard JP, Brink C, Norel X.

3/ Modulation of bradykinin B2 receptors and mRNA by methylprednisolone in guinea-pig tracheal smooth muscle cells.
Scherrer D, Schmidlin F, Landry Y, Gies JP.

4/ Salmeterol but not formoterol antagonises short – acting ß2 adrenoceptor agonists in human isolated contracted bronchi.
Molimard M, Naline E, Zhang Y, Le Gros V, Advenier C.

Session XVII Pharmaco-épidémiologie, Pharmacovigilance, Information thérapeutique

Modérateurs : JOUGLARD J. BLAYAC J.P.

1/ Pharmacoeconomic evaluation of botulinum toxin in the treatment of spasmodic torticollis.
Brefel C, Simonetta-Moreau M, Moré C, Lapeyre-Mestre M, Rascol O, Montastruc JL.

2/ Plasma coenzyme Q10 concentrations in breast cancer : prognosis and therapeutic consequences.
Jolliet P, Simon N, Pons JY, Boukef FM, Barré J, Paniel BJ, Tillement JP.

3/ Pharmacovigilance in French high schools : hepatitis B vaccination of pupils in the Bas-Rhin department.
Haan MC, Welsch M, Alt M, Veyriac E, Imbs JL.

4/ Drug consumption in workers in France : a comparative study between 1986 and 1996.
Chastan E, Louis A on behalf of the \”Service Medical Interentreprises\”, Montastruc JL.

5/ Epidas : a randomised controlled clinical trial to assess the efficacy of the transmission of therapeutic information.
Boissel JP, Haugh M, Cucherat M, Brun C, Gauthier E.

6/ Impact of trials with null number of events in meta-analysis.
Cucherat M, Leizorovicz A, Boissel JP.

Session XVIII Pharmacologie broncho-pulmonaire

Salle Podesta


1/ 11 h 30 Characterization of G protein involved in secretory process of rat mast cell line transfeced with muscarinic M1 receptor (RBL-2H3 (m1)).
Chahdi A, Mousli M, Landry Y.

2/ 11 h 45 Tissular variation of adenosine analogues relaxant activity in the guinea-pig isolated trachea and aorta.
Laurent F, Portet K, Gasc F, Michel A.

3/ 12 h 00 Effects of acetylcholine and substance P on the mechanical properties of isolated perfused rabbit lungs : pharmacological mechanisms.
Delaunois A, Gustin P.

4/ 12 h 15 Influence of diabetes mellitus on the development of airway inflammation in sensitized and challenged rats.
Sannomiya P, Boichot E, Miguel AS, Escofier N, Schumacher RI, Germain N, Lagente V, Fortes ZB.

5/ 12 h 30 Human airway hyperresponsiveness to bradykinin induced by endotoxin and interleukin 1ß, in vitro.
Molinard M, Naline E, Devillier P, Boichot E, Lagente V, Advenier C.

6/ 12 h 45 Bronchodilator response in asthmatic children exposed to environmental tobacco smoke.
Dubus JC, Badier M, Guillot C, Oddoze C, Bruguerolle B.

Session XIX Pharmacologie clinique, thérapeutique



1/ 11 h 30 Glutathione S-transferase (GST) genetic polymorphisms and tacrine hepatotoxicity in alzheimer’s disease.
Becquemont L, Lecoeur S, Simon T, Beaune P, Funck-Brentano C, Jaillon P.

2/ 11 h 45 Effects of beraprost sodium in intermittent claudication : results of berci-2, a randomized, placebo-controlled, double blind study.
Lièvre M, Morand S, Lion L, Boissel JP.

3/ 12 h 00 An ongoing meta-analysis of homeopathic medecine. Specific problems met.
Cucherat M, Boissel JP, Haugh M, on behalf the HMRAG group.

4/ 12 h 15 Meta-analysis of randomized clinical trials of beta-blocker treatment in heart failure.
Lechat P, Chalon S, Cucherat M, Arab T, Packer M, Boissel JP.

5/ 12 h 30 Towards a better understanding of what the “level of evidence” is, and how it can be evaluated.
Bossard N, Boissel JP, Duru G, Haugh M.

6/ 12 h 45 Education program for general practitioners on breast and cervical cancer screening : a randomized trial.
Boissel JP, Collet JP, Alborini A, Cordel JC, Filsnoel J, Gillet J, Nemoz C, Brémond A, Bernhard G, Bourdin JF, Muller B, Knopf JF, the PRE.SA.GE Collaborative Group.

Session XX: SYMPOSIUM : Pharmacologie des maladies neurodégénératives

Amphithéâtre 14 h 15 – 18 h 15

Modérateurs : BLIN O. BOURIN M.

1/ 14 h 15 Bases cellulaires des processus neurodégénératifs.
Niéoullon A.

2/ 14 h 45 Perspectives des thérapies cellulaires et génétiques.
Revah F.

3/ 15 h 15 Approche pharmacologique des dysautonomies.
Senard J.M.

15 h 45 Pause

4/ 16 h 15 Du développement clinique à la gestion de la maladie.
Rascol O, Blin O.

5/ 16 h 45 Pharmacovigilance.
Begaud B.

6/ 17 h 15 Prions, aspects Pharmacologiques et état actuel des connaissances.
Dormond D., Deslys J.P.