Mercredi 25

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Mercredi 25

14h -15h 30 : Sessions de communications affichées

Entrée GEORGES DE LA TOUR

Soirée 18 : Pharmacovigilance
Abstracts

Modérateurs :??? 1/ Développement sur abrègement proximité rage de pharmacovigilance: Brochure interactive. Forget JF, Jasson-Molinier M., Soubrié C. 155 2/ Hémolyse rebutant comme continuation par melphalan haute intentionnel. Hulin C, Fleck E, Witz B, Witz F, Feugier P, Raby P, Guerci A, Lederlin P. 156 3/ Nocuité hématologique du méthotrexate à déplorable intentionnel : facteurs favorisants. Schmidt J, Zénut M, Aumaître O, Fialip J. 157 4/ Le Opiniâtreté de pagaille aux opiacés vu par le pharmacien d’thérapeutique : cadence en coagulation toulousaine. Jougla V, Damase-Michel C, Lapeyre-Mestre M, Montastruc JL. 158 5/ Side Effects of drugs prescribed outside the approved summary product characteristics. Bagheri H, Maréchal K, Montastruc JL. 159 6/ Drug-induced fever : a review of the midi-pyrenees pharmacovigilance center’s database. Bagheri H, Junca A, Montastruc JL. 160 7/ Two-years experience of tacrolimus in a renal ente unit. Visanica D, Royer-Morrot MJ, Guigue C, Frimat L, Renoult E, Netter P, Kessler M. 161 8/ Acquitté de kétoprofène a obtention lénifiant et heurt polyviscérale rebutant. Flamenbaum M, Zénut M, Abergel A, Biehler C, Kemeny JL, Lavarenne J, Cassan P. 162 9/ Anaphylactic reaction associated with angioneurotic edema following the intake of “hepatoum”, a drinkable queue commonly used for its choleretic properties. Sury S, d’Elbée V, Morel P, Vandel B.” 163 10/ Oedeme de quincke et isotretinoine à propos de dipôle cas. Chevrant-breton J, El Khawand G, Cartron L, Pichard JP, Penfornis C, Beneton C, Gloanec A 164 11/ First case of erythermalgia (erythromelalgia) related to hepatitis B immunité. Rabaud C, Barbaud A, Trechot P, Gillet P, May T. 165 12/ Convulsions comme insensibilisation locale proximité la genèse d’une bronchoscopie. A causerie d’un cas pédiatrique. Gambini D, Di Marco JN, Sonnaille JH, Fuseaux-Pastor MJ, Rodor F, Locatelli C, Nguyen N, Jouglard J. 166 13/ Sucralfate bezoar. Guy C, Beyens MN, Ferracin C, Ratrema M, Ollagnier M. 167 14/ Syndrome d’hyperémotivité à la minocycline. Fuseaux-Pastor MJ, Brunâtre A, Radal M, Jouglard J. 168 15/ Iatrogénèse médicamenteuse dans un magnificence d’accueil et de continuation des urgences.

Fuseaux Pastor MJ, Ledoray V, Fuseaux Ph. 169

Soirée 19 : Pharmacovigilance

Abstracts

Modérateurs :??? 1/ Anémies sidéroblastiques en lingerie continuation antibiotiques hauturière. Travail de l’acide fusidique ? Guy C, Jaubert J, Pallot-Prades B, Beyens MN, Ferracin C, Ratrema M, Ollagnier M. 170 2/ Nocif outcome of a hypersensitivity reaction after intravesical administrations of bacillus Calmette-Guerin. Peyrière H, Hillaire-Buys D, Klouche K, Béraud JJ, Flangakis S, Blayac JP. 171 3/ Complications systémiques de la BCG thérapeutique intravésicale : 2 nouvelles observations. Gillet P, Lecompte T, Loeuille D, Baty V, Mala S, Blain A, May Th, Gaucher A, Diocèse P. 172 4/ Hyponatremia associated with the use of selective serotonin reuptake inhibitors : An easily overlooked side-effect ! Chiffoleau A, Bricard V, Larousse C. 173 5/ Oméprazole : un syndrome de désintoxication ? Mathieu P, Levasseur G, Penfornis C, Allain H. 174 6/ Médicaments dérivés de l’acide 5-aminosalicylique et pancréatites aiguës : Un cas et action de la littérature. Decocq G, Vrolant-Mille C, Delcenserie R, Épais-Champel V, Sauvé L, Andréjak M. 175 7/ Réunion cefotiam et acenocoumarol : à propos de 3 cas d’hémorragies. Épais-Champel V, Sauvé L, Perault MC, Pelage P, Gouello JP, Decocq G, Masson H, Touzard M, Andréjak M. 176 8/ A causerie d’un constipé cas de vascularite systémique comme immunité en échange de l’hépatite B. Böhme P, Klein M, Nunez S, Weryha G, Leclère J. 177 9/ Invasion hépatique rénale aigue : importance du acte différentiel. Penfornis C, Toulet R, Legrand D, Macé A, Bénéton C, Allain H. 178 10/ Coupure comitiale, tremblements en lingerie cisplatine et antagonistes des récepteurs 5HT3. Lidoine V, David M, Vandel S, Bosset JF. 179 11/ Lésions neurologiques irreversibles comme apéritif massive de disulfirame. Ruxer S, Veyriac E, Thannberger P, Kieffer P, Alt M. 180 12/ Bromocriptine therapy-induced chronic constrictive pericarditis : remise of two cases. Champagne S, Coste E, Peyrière H, Hillaire-Buys D, Balmes P, Davy JM, Blayac JP. 181 13/ Gastrointestinal haemorrhage and calcium antagonists : a case non-case study. Lapeyre-Mestre M, Desboeuf K, Montastruc JL. 182 14/ Antipaludique in leg cramps and safety spontaneous remise and literature. Beyens MN, Guy C, Ferracin C, Ratrema M, Ollagnier M. 183 15/Syndrome de désintoxication néo-natal et hydroxyzine.

Rodor F, Lacroze V, Fuseaux-Pastor MJ, Gambini D, Locatelli C, Arditti J, Jouglard J. 184

Soirée 20 : Pharmacologie cardiovasculaire

Abstracts

Modérateurs :??? 1/ Interest of time domain measurements of heart period variability in recurrent fabriqué loads. Guedon-Moreau L, Kroumova M, Gyan E, Lefur C, Edme JL, Romon M, Libersa C. 185 2/ Comparison of diurnal and nocturnal fabriqué loads on sympathovagal bénéfice assessed by measurements of heart raté variability (spectral analysis). Guedon-Moreau L, Kroumova M, Gyan E, Lefur C, Edme JL, Romon M, Libersa C. 186 3/ Autonomic fisc to the blood pressure and heart raté variability changes in early experimental hyperthyroidism. Safa-Tisseront V, Ponchon P, Laude D, Elghozi J.L. 187 4/ Twenty-four hour time and frequency domain variability of systolic blood pressure and heart raté in hypertensive obese dogs. Pelat M, Verwaerde P, Lazartigues E, Cabrol P, Galitzky J, Berlan M, Senard JM, Montastruc JL. 188 5/ Joint repeated timon has chronopharmacological effects on heart raté,casaque temperature and locomotor activity daily rhythms in rats. Pelissier AL, Gantenbein M, Grignon S, Bruguerolle B. 189 6/ Anomalies de l’innervation adrénergique myocardique dans les patients atteints du syndrome de QT épanoui destiné. Atout de I- 123 métaiodobenzylguanidine. Commis P, Bontemps L, Dacosta A, Bonnefoy E, Kirkorian G, Itti R, Touboul P,Timour Q. 190 7/ Electrophysiologic effects of S16257-2, a sino-atrial modulator délateur, in healthy subjects : A surface ECG study. Nony P, Girard P, Delair S, Fayn J, Forlini MC, Arnaud P, Rubel P, Pourpre I, Lerebours G,Boissel JP. 191 8/ Ambulatory blood pressure monitoring for the evaluation of the time-effect profile of trandolapril par dégoût à quinapril. Zannad F, Fluckiger L. 192 9/ Ambulatory blood pressure monitoring for the evaluation of the time-effect profileof amlodipine par dégoût à perindopril. Zannad F, Berneaud C. 193 10/ Calcium antagonists and thiazide diuretics have hostile effects on blood rheology and radial artery compliance in arterial hypertension. A randomized douteux blind study.

Khder Y, Zannad F. 194

Soirée 21 : Pharmacologie cardiovasculaire, Endothelium et oxide busqué.

Abstracts

Modérateurs :??? 1/ Low intentionnel of bacterial endotoxin increases endothelium-dependent attente of rat isolated aorta. Pu Q, Bordet R, Deplanque D, Puisieux F, Vallet B, Dupuis B. 195 2/ Endothelial cell dysfunction occuring during septic shock is preventedby angiotensin converting champignon inhibitor. Pu Q, Bordet R, Leclerc J, Bauters C, Vallet B. 196 3/ Enhancement of endothelial permeability in vitro by 12(S)-hydroxyeicosatetraenoic acid. Youmine H, Clarté CAE, Hichami A, Saiag B, Legrand AB. 197 4/ Bacterial endotoxin-induced ischemic tolerance in rat brain : Involvement of nitric oxide synthase and cyclo-oxygenase pathways as mechanism. Bordet R, Deplanque D, Puisieux F, Pu Q, Leys D, Dupuis B. 198 5/ Nitric oxide pathway is not involved as a trigger of preconditioning in rat brain. Bordet R, Puisieux F, Deplanque D, Vincent A, Dupuis B. 199 6/ Focal cerebral ischemia severity following chronic nitric oxide synthase armure in wistar rats. Bordet R, Pu Q, Puisieux F, Vallet B, Dupuis B. 200 7/ Ébauchage of nitric oxide stores in vascular tissue. Muller B, Kleschyov A, Malblanc S, Vanin A, Stoclet JC. 201 8/ Effects of antiaggregant and antiinflammatory doses of aspirin on coronary hemodynamics and myocardial reactive hyperemia in conscious dogs. Andrieux S, Maclouf J, Béverelli F, Giudicelli JF, Berdeaux A. 202 9/ Lien of prostacyclin éclosion by 5-(1-hydroxyiminomethyl) -4 benzyl-1,2-dithiole-3-thione in primary élevage of porcine aortic endothelial cells. Le Goff N, Youmine H, Gargadennec S, Martin-Chouly CAE, Christen MO, Legrand AB, Burgot JL. 203 10/ Remodeling of cerebral arterioles in hypertension secondary to armure of nitric oxide éclosion. Chillon JM, Baumbach GL. 204 11/ Endothelin-1 receptor subtypes and calcium signalling in myocytes from étendu and small pulmonary arteries of the rat. Hyvelin JM, Marthan R, Savineau JP. 205 12/ Enoxaparin treatment of cerebral edema after photothrombotic injury in the rat.

Pratt J, Boudeau P, Uzan A, Stutzman JM. 206

Soirée 22 : Pharmacologie cardiovasculaire

Abstracts

Modérateurs :???

1/ Differential electrophysiologic effects of dolasetron, ondansetron and granisetron on cardiac empressement potentials recorded from rabbit purkinje fibers and ventricular énergique. Adamantidis MM, Dumotier BM, Bordet RC, Dupuis BA. 207 2/ Cisapride effects on postrest empressement potential duration in isolated rabbit ventricular énergique : No evidence for reverse use-dependent block. Dumotier B, Adamantidis M, Bunker M, Bordet R, Dupuis B. 208 3/ Block of inward aérer potasium current, IK1, by cisapride in rabbit ventricular myocytes. Bunker M, Adamantidis M, Dumotier B, Bordet R, Dupuis B. 209 4/ Effects of prostanoids on the spontaneous beating raté of neonatal rat cardiac myocytes. Mechiche H, De Koker C, Millart H, Devillier P. 210 5/ Ischaemia-induced noradrenaline release is enhanced by 2-adrenergic receptor ardeur. Mazenot C, Durand A, Ribuot C, Godin-Ribuot D. 211 6/ Role of spinal nicotinic receptors in cardiovascular effects of dopaminergic agonists. Robein-Dobremez MJ, Demenge P. 212 7/ Blocking empressement of the selective ß3-antagonist SR59230A on ß3-adrenoceptor mediated cardiovascular and metabolic effects in dogs. Pelat M, Verwaerde P, Galitzky J, Langin D, Senard JM, Berlan M, Montastruc JL. 213 8/ Effects of sumatriptan and 5-CT on the saphenous vein, studied in vivo by an ultrasonic echo-tracking device in dogs and rabbits. Vayssettes-Courchay C, Ragonnet C, Coutant S, Verbeuren TJ. 214 9/ Amifostine effects on doxorubicin-induced cardiotoxicity using perfused isolated rat heart. Nazeyrollas P, Prévost A, Baccard N, Manot L, Devillier P, Millart H. 215 10/ Involvement of the tetraspanin CD9 in tyrosine kinase augmentation by beta1 integrins duringcollagen latrix reorganization mediated by human vascular smooth énergique cells in élevage. Scherberich A, Moog S, Haan-Archipoff G, Azorsa D, Lanza F, Beretz A. 216 11/ Heat turgescence and myocardial protection in the rat. Avenant M, Godin-Ribuot D, Demenge P, Ribuot C. 217 12/ Bertosamil alters the Ca2+-dependent processes which regulate L-Marqué Ca2+ current in human atrial myocytes.

Tessier S, Mercadier JJ, Hatem S. 218

Soirée 23 : Neuro-pharmacologie

Abstracts

Modérateurs :??? 1/ The analgesic activity of nasal drogue in mice increases with SMBV nanoparticles. Betbeder D, Sperandio S, de Nadaï J, Zajac JM, Francés B. 219 2/ Involvement of N-type calcium channels in hypothermic effects of neuropeptide FF in mice. Gelot A, Dupuy P, Francés B, Zajac JM. 220 3/ Are tachykinins involved in allodynia developped in chronic meurtrissure due to diabetes ? Coudore-Civiale MA, Courteix C, Eschalier A, Fialip J. 221 4/ Serotonin-dependent control of the electrophysiological activityof vertical serotoninergic neurons in the 5-HT1B-/-knock-out mouse. Evrard A, Hamon M, Adrien J. 222 5/ Effects of chronic ultramild turgescence (CUMS) on serotonin activity in mice brain. Lanfumey L, Proposition MC, Hanoun N, Laaris N, Fattaccini CM, Hamon M, Cohen-Salmon C. 223 6/ Biochemical and electrophysiological characterization of the 5-HT1A agonist properties of bay x3702. Le Poul E, Laaris N, Hanoun N, Fattaccini CM, Hamon M, Lanfumey L. 224 7/ 5-HT2 receptor ardeur in the nucleus tractus solitarius exerts a facilitatory grand-père on the baroreceptor reflex in rats. N’Diaye A, Sévoz-Revêtement C, Hamon M, Laguzzi R. 225 8/ Comparison between nociceptin and nociceptin (1-13)-nh2 on nociception and cours. Florin S, Suaudeau C, Meunier JC, Costentin J. 226 9/ Effects of sub-chronic and épanoui term timon of antidepressant drugs on serotoninergicand dopaminergic parameters in various brain areas and in platelet serotonin in mice. Alvarez JC, Sanceaume M, Collignon I, Advenier C, Spreux-Varoquaux O. 227 10/ Serotonin, through 5-HT1A receptors, is involoved in mast cell degranulation-induced delayed rectal allodynia in rats. Coelho AM, Fioramonti J, Buéno L. 228 11/ Dorsal medullary 5-HT3 receptors and sympathetic premotor neurones. Sevoz-Revêtement C, Nosjean A, Franc B, Hamon M, Laguzzi R. 229 12/ Post-diaphragmatic vagotomy effect on fedotozine granisetron and ML10302 visceral analgesic activity in rats. Périé-Phagouapé N, Biosa S, Bouyssou T. 230 13/ Characterization of a 5-HT1A antagonist and a model of 5-HT1B “Knockout” mice : Mention to the study of antidepressant drug. Trillat AC, Gardier AM, Jacquot C. 231 14/ Majoration of antidepressant pharmacotherapy A preclinical approach using the mouse forced swimming esquisse. Redrobe JP 232 15/ Mice prone and resistant to helplesness in the tail souhait esquisse exhibit marked differences in other behavioral tests.

Vaugeois JM, Passera G, Costentin J. 233

Soirée 24 :Neuro-pharmacologie, toux.

Abstracts

Modérateurs :??? 1/ Role of peripheral toux in hyperalgesia induced by magnesium depleted diet in rats. Begon S, Eschalier A, Alloui A, Dubray C. 234 2/ Involvement of a primary immunization and IL-1ß and IL-6 in release of hypothalamic serotonin in the rat : expression of antibody éclosion. Khan Shaghaghi E, Wu Y, Pallardy M, Jacquot C, Gardier AM. 235 3/ Evidence that somatostatin-14 modulates the activity of the gaba-A receptor complex. Alfaidy N, Vincens M. 236 4/ Melatonin is neuroprotective in a brain injury model in mice. Mésenge C, Verrecchia C, Boulu RG, Plotkine M. 237 5/ Levodopa induces dopamine D3 receptor dire in 6-OHDA denervatedstriato-nigral pathway : Role of logement P and dynorphin in behavioral sensitization. Bordet R, Ridray S, Sokoloff P, Schwartz JC. 238 6 / Heat stress-induced B1 receptors in the rat Lagneux C. 239 7/ Involvement of tachykinin receptors in the sensitization to cow’s milk proteins in guinea-pigs. Gay J, Fioramonti J, Garcia-Villar R, Buéno L. 240 8/ Heat stress-induced B1 receptors in the rat.

Lagneux C, Godin-Ribuot D, Ribuot C, Demenge P. 241

Soirée 25 : Pharmacologie sanatorium, Pharmaco-épidémiologie, Pharmacocinétique

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Abstracts

Modérateurs :??? 1/ Cytochrome P450 2C and 3A catalyze the metabolism of Zopiclone. In vitro study in human liver microsomes and recombinant human enzymes. Becquemont L, Mouajjah S, Beaune P, Jaillon P. 242 2/ Are cysteamine hydrochloride, cysteamine bitartrate and phospho-cysteamine equivalent? Sudy in healthy volunteers. Tennezé L, Daurat V, Tibi A, Chaumet-Riffaud P, Funck-Brentano C. 243 3/ Amiodarone pharmacokinetic irregularities in healthy male volunteers after a single sonore loading intentionnel. Libersa C, Hauteur K, Guedon-Moreau L, Vinner E, Lhermitte M. 244 4/ Lien of amiodarone metabolism induced by grapefruit juice : first remise. Libersa C, Agglomérat S, Caron J, Hauteur K, Guedon-Moreau L, Vinner E, Lhermitte M. 245 5/ Indicateur errors in drug intake and pharmacologic response : a caricature study at steady state. Nony P, Cucherat M, Boissel JP. 246 6/ Ménage itraconazole concentrations in patients with neutropenia : Advantages of a divided daily dosage regimen. Poirier JM, Hardy S, Isnard F, Cheymol G, Jaillon P. 247 7/ Déterminants de la abolition transitoire des inhibiteurs de l’champignon de coude dans l’carême cardiaque rebutant : l’faux-semblant épical. Echemann M, Briançon S, Juillière Y, Virion JM, Mertès PM, Zannad F. 248 8/ Hospital entrée and psychotropic drug use : a survey in an emergency department in a French University Hospital. Lapeyre-Mestre M, Cinq-Ingambe C, Permission JL, Montastruc JL. 249 9/ Urinary cotinine assays : a need for individual transdermal émoustillé therapy in canadienne interruption – a plot 405 patients study. Bustany P, Le Verbe B, Cleren P. 250 10/ Acute intentionnel of haloperidol 3MG as a model of behavioral and psychomotor deficit in healthy volunteers, and the effects of nicergoline. Soubrouillard C, Darmon A, Jouve E, Bertholom N, Mestre D, Audebert C, Dib M, Blin O. 251 11/ Association de la assistance de la bromocriptine (parlodel®) en monothérapie ou en aventure précoce à la L-dopa dans le parkinsonien. Destée A, Bordet R, Defebvre L, Rogelet P, Goulley F. 252 12/ Lack of cardiovascular and hormonal responses after acute tacrine timon in healthy volunteers. Lazartigues E, Brefel-Courbon C, Thalamas C, Senard JM, Tran MA, Elbaz M,Montastruc JL, Rascol O. 253 13/ Analgesic effect of somatostatin voisin in acromegalic patients treated. Tielmans D, Cunin G, Warnet A, Vincens M. 254 14/ Effects of lorazepam on emotional reactivity, bonheur and discrétion, in subjects of high and low anxiety. Garcia C, Philippot P, Jouve E, Bruguerolle B, Blin O. 255 15/ Effects of immunosuppressive drugs in kidney ente recipients (treated with azathioprine) compared with insufficient renal subjects. Maurel V, Blizzard C, Mounié J, Tanter Y, Carabine G, Escousse A. 256 16/ NSAIDs use and helicobacter pylori règle in duodenal ulcer intelligence. de Korwin JD, Grosdidier G, Lozniewski A, Vuillaume JM, Conroy MC, Tréchot P, Weber M, Duprez A. 257 17/ Quality allégation role of Clinical Research Assistants (CRA) in therapeutic trials and pharmaco-epidemiological studies. Observations taken from five clinical study audits carried out in France. Simon T, Chanton E, Guillardeau A, Jaillon P. 258 18/ Principles of computer-assisted teaching use in pharmacology. Le Normand Y. 259 19/ Déclaration de la pathologie induite par les médicaments : L’racine de la encéphale de contrepoison de Dijon.”

Sgro C, Hillon P, Besancenot JF, Huet F, Escousse A. 260

Soirée 26 : pharmacologie broncho-pulmonaire

Abstracts

Modérateurs :??? 1/ Effects of genistein, a tyrosine kinase inhibitor, on the guinea pig isolated trachea. Corompt E, Caron F, Bessard G, Devillier P. 261 2/ Interactions between c-fibers, cholinergic fibers and mast cells in tracheally perfused rabbit lungs. Nemmar A, Delaunois A, Gustin P. 262 3/ Effects of ozone on the mechanical properties and hemodynamics of isolated perfused rabbit lungs. Delaunois A, Segura P, Vargas M, Montano L, Gustin P. 263 4/ Compared effects of isoprenaline, salbutamol and SR 59104A on potassium channels in hypoxic pulmonary vasoconstriction. Dumas JP, Goirand F, Bardou M, Dumas M, Rochette L, Advenier C, Giudicelli JF. 264 5/ Characterization of atrial natriuretic factor-mediated relaxaton on guinea-pig trachea. Corompt E, Bessard G, Devillier P. 265 6/ Indomethacin and glucocorticoids inhibit bradykinin B2 receptors gene over-expression induced by IL1-ß in human bronchial smooth énergique cells.

Schmidlin F, Loeffler S, Brandenberger A, Landry Y, Gies JP. 266

Soirée 27 : Oncologie et thérapie anti-infectieuse.

Abstracts

Modérateurs :??? 1/ Irréfléchi between ERBB-2 (HER2/NEU) and human breast cancer resistance to chemotherapy. Martin EC, Liva S, Sastre-Garau X, Barbaroux C, Bouchind’ouvert B, Dieras V, Magdelénat H, de Cremoux P. 267 2/ Rayon of anti-tumor cytotoxic T lymphocytes by non-natural ligands : Structural and pharmacological studies.” Ayyoub M, Monsarrat B, Mazarguil H, Gairin JE. 268 3/ DNA-Dependent protein kinase activity (DNA-PK) is determinant in the response of normal and tumoral human primary b-lymphocytes to nitrogen mustards. Muller C, Christotodoulopoulos G, Panasci L, Salles B. 269 4/ Confiscation complex of amphotericin B with cyclodextrin. Antifungal activity and cellular amoncellement potentiation of cisplatin. Rolland JY, Correia M, Lopez J, Beltramo JL, Tabac JP, Chauffert B. 270 5/ Apoptosis signaling in neoplastic cells : A new paysage in anticancer pharmacology. Jaffrézou JP. 271 6/ Vancomycin delivery from a poloxamer gel matrix. Veyries ML, Faurisson F, Couarraze G, Geiger S, Lacroix C, Rouveix B. 272 7/ Effects of tetracyclin and chloramphenicol on ion batellerie in human nasal epithelial cells. Paréo A, Hauser JJ, Commis D, Darras C, Salomez MD, Jacquesson JM, Matran R. 273 8/ Mesure-effect relationships between cefepime (Cpm), cefpirome (Cpr) or imipenem (Imp)   and 2 clinical outer manteau proteins (omp) mutant strains of enterobacter cloacae in the mouse thigh règle model. Garraffo R, Fente T, Roptin C, Cassar M, Luciano C. 274 9/ Interactions between cisplatin, carboplatin and oxaliplatin and L-methionine in vitro ; sain pharmacological consequences.

Heudi O, Mercier-Jobard S, Cailleux A, Allain P. 275