Mercredi 25

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Mercredi 25

14h -15h 30 : Sessions de communications affichées

Salle GEORGES DE LA TOUR

Session 18 : Pharmacovigilance
Abstracts

Modérateurs :??? 1/ Logiciel sur mesure pour centre de pharmacovigilance: Présentation interactive. Forget JF, Jasson-Molinier M., Soubrié C. 155 2/ Hémolyse sévère après traitement par melphalan haute dose. Hulin C, Fleck E, Witz B, Witz F, Feugier P, Raby P, Guerci A, Lederlin P. 156 3/ Toxicité hématologique du méthotrexate à faible dose : facteurs favorisants. Schmidt J, Zénut M, Aumaître O, Fialip J. 157 4/ Le Traitement de substitution aux opiacés vu par le pharmacien d’officine : enquête en agglomération toulousaine. Jougla V, Damase-Michel C, Lapeyre-Mestre M, Montastruc JL. 158 5/ Side Effects of drugs prescribed outside the approved summary product characteristics. Bagheri H, Maréchal K, Montastruc JL. 159 6/ Drug-induced fever : a review of the midi-pyrenees pharmacovigilance center’s database. Bagheri H, Junca A, Montastruc JL. 160 7/ Two-years experience of tacrolimus in a renal transplant unit. Visanica D, Royer-Morrot MJ, Guigue C, Frimat L, Renoult E, Netter P, Kessler M. 161 8/ Prescription de kétoprofène a visée antalgique et atteinte polyviscérale sévère. Flamenbaum M, Zénut M, Abergel A, Biehler C, Kemeny JL, Lavarenne J, Cassan P. 162 9/ Anaphylactic reaction associated with angioneurotic edema following the intake of \”hepatoum\”, a drinkable solution commonly used for its choleretic properties. Sury S, d’Elbée V, Morel P, Vandel B.” 163 10/ Oedeme de quincke et isotretinoine à propos de deux cas. Chevrant-breton J, El Khawand G, Cartron L, Pichard JP, Penfornis C, Beneton C, Gloanec A 164 11/ First case of erythermalgia (erythromelalgia) related to hepatitis B vaccination. Rabaud C, Barbaud A, Trechot P, Gillet P, May T. 165 12/ Convulsions après anesthésie locale pour la réalisation d’une bronchoscopie. A propos d’un cas pédiatrique. Gambini D, Di Marco JN, Bourdon JH, Jean-Pastor MJ, Rodor F, Locatelli C, Nguyen N, Jouglard J. 166 13/ Sucralfate bezoar. Guy C, Beyens MN, Ferracin C, Ratrema M, Ollagnier M. 167 14/ Syndrome d’hypersensibilité à la minocycline. Jean-Pastor MJ, Brun A, Radal M, Jouglard J. 168 15/ Iatrogénèse médicamenteuse dans un service d’accueil et de traitement des urgences.

Jean Pastor MJ, Ledoray V, Jean Ph. 169

Session 19 : Pharmacovigilance

Abstracts

Modérateurs :??? 1/ Anémies sidéroblastiques sous traitement antibiotiques au long cours. Rôle de l’acide fusidique ? Guy C, Jaubert J, Pallot-Prades B, Beyens MN, Ferracin C, Ratrema M, Ollagnier M. 170 2/ Fatal outcome of a hypersensitivity reaction after intravesical administrations of bacillus Calmette-Guerin. Peyrière H, Hillaire-Buys D, Klouche K, Béraud JJ, Flangakis S, Blayac JP. 171 3/ Complications systémiques de la BCG thérapie intravésicale : 2 nouvelles observations. Gillet P, Lecompte T, Loeuille D, Baty V, Mala S, Blain A, May Th, Gaucher A, Canton P. 172 4/ Hyponatremia associated with the use of selective serotonin reuptake inhibitors : An easily overlooked side-effect ! Chiffoleau A, Bricard V, Larousse C. 173 5/ Oméprazole : un syndrome de sevrage ? Mathieu P, Levasseur G, Penfornis C, Allain H. 174 6/ Médicaments dérivés de l’acide 5-aminosalicylique et pancréatites aiguës : Un cas et revue de la littérature. Decocq G, Vrolant-Mille C, Delcenserie R, Gras-Champel V, Sauvé L, Andréjak M. 175 7/ Association cefotiam et acenocoumarol : à propos de 3 cas d’hémorragies. Gras-Champel V, Sauvé L, Perault MC, Laine P, Gouello JP, Decocq G, Masson H, Touzard M, Andréjak M. 176 8/ A propos d’un nouveau cas de vascularite systémique après vaccination contre l’hépatite B. Böhme P, Klein M, Nunez S, Weryha G, Leclère J. 177 9/ Atteinte hépatique rénale aigue : importance du diagnostic différentiel. Penfornis C, Toulet R, Legrand D, Macé A, Bénéton C, Allain H. 178 10/ Crise comitiale, tremblements sous cisplatine et antagonistes des récepteurs 5HT3. Lidoine V, David M, Vandel S, Bosset JF. 179 11/ Lésions neurologiques irreversibles après ingestion massive de disulfirame. Ruxer S, Veyriac E, Thannberger P, Kieffer P, Alt M. 180 12/ Bromocriptine therapy-induced chronic constrictive pericarditis : report of two cases. Champagne S, Coste E, Peyrière H, Hillaire-Buys D, Balmes P, Davy JM, Blayac JP. 181 13/ Gastrointestinal haemorrhage and calcium antagonists : a case non-case study. Lapeyre-Mestre M, Desboeuf K, Montastruc JL. 182 14/ Quinine in leg cramps and safety spontaneous report and literature. Beyens MN, Guy C, Ferracin C, Ratrema M, Ollagnier M. 183 15/Syndrome de sevrage néo-natal et hydroxyzine.

Rodor F, Lacroze V, Jean-Pastor MJ, Gambini D, Locatelli C, Arditti J, Jouglard J. 184

Session 20 : Pharmacologie cardiovasculaire

Abstracts

Modérateurs :??? 1/ Interest of time domain measurements of heart period variability in recurrent mental loads. Guedon-Moreau L, Kroumova M, Gyan E, Lefur C, Edme JL, Romon M, Libersa C. 185 2/ Comparison of diurnal and nocturnal mental loads on sympathovagal balance assessed by measurements of heart rate variability (spectral analysis). Guedon-Moreau L, Kroumova M, Gyan E, Lefur C, Edme JL, Romon M, Libersa C. 186 3/ Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism. Safa-Tisseront V, Ponchon P, Laude D, Elghozi J.L. 187 4/ Twenty-four hour time and frequency domain variability of systolic blood pressure and heart rate in hypertensive obese dogs. Pelat M, Verwaerde P, Lazartigues E, Cabrol P, Galitzky J, Berlan M, Senard JM, Montastruc JL. 188 5/ Nicotine repeated administration has chronopharmacological effects on heart rate,body temperature and locomotor activity daily rhythms in rats. Pelissier AL, Gantenbein M, Grignon S, Bruguerolle B. 189 6/ Anomalies de l’innervation adrénergique myocardique chez les patients atteints du syndrome de QT long acquis. Intérêt de I- 123 métaiodobenzylguanidine. Chevalier P, Bontemps L, Dacosta A, Bonnefoy E, Kirkorian G, Itti R, Touboul P,Timour Q. 190 7/ Electrophysiologic effects of S16257-2, a sino-atrial modulator agent, in healthy subjects : A surface ECG study. Nony P, Girard P, Delair S, Fayn J, Forlini MC, Arnaud P, Rubel P, Violet I, Lerebours G,Boissel JP. 191 8/ Ambulatory blood pressure monitoring for the evaluation of the time-effect profile of trandolapril versus quinapril. Zannad F, Fluckiger L. 192 9/ Ambulatory blood pressure monitoring for the evaluation of the time-effect profileof amlodipine versus perindopril. Zannad F, Berneaud C. 193 10/ Calcium antagonists and thiazide diuretics have opposite effects on blood rheology and radial artery compliance in arterial hypertension. A randomized double blind study.

Khder Y, Zannad F. 194

Session 21 : Pharmacologie cardiovasculaire, Endothelium et oxide nitrique.

Abstracts

Modérateurs :??? 1/ Low dose of bacterial endotoxin increases endothelium-dependent relaxation of rat isolated aorta. Pu Q, Bordet R, Deplanque D, Puisieux F, Vallet B, Dupuis B. 195 2/ Endothelial cell dysfunction occuring during septic shock is preventedby angiotensin converting enzyme inhibitor. Pu Q, Bordet R, Leclerc J, Bauters C, Vallet B. 196 3/ Enhancement of endothelial permeability in vitro by 12(S)-hydroxyeicosatetraenoic acid. Youmine H, Matin CAE, Hichami A, Saiag B, Legrand AB. 197 4/ Bacterial endotoxin-induced ischemic tolerance in rat brain : Involvement of nitric oxide synthase and cyclo-oxygenase pathways as mechanism. Bordet R, Deplanque D, Puisieux F, Pu Q, Leys D, Dupuis B. 198 5/ Nitric oxide pathway is not involved as a trigger of preconditioning in rat brain. Bordet R, Puisieux F, Deplanque D, Vincent A, Dupuis B. 199 6/ Focal cerebral ischemia severity following chronic nitric oxide synthase inhibition in wistar rats. Bordet R, Pu Q, Puisieux F, Vallet B, Dupuis B. 200 7/ Formation of nitric oxide stores in vascular tissue. Muller B, Kleschyov A, Malblanc S, Vanin A, Stoclet JC. 201 8/ Effects of antiaggregant and antiinflammatory doses of aspirin on coronary hemodynamics and myocardial reactive hyperemia in conscious dogs. Andrieux S, Maclouf J, Béverelli F, Giudicelli JF, Berdeaux A. 202 9/ Inhibition of prostacyclin production by 5-(1-hydroxyiminomethyl) -4 benzyl-1,2-dithiole-3-thione in primary culture of porcine aortic endothelial cells. Le Goff N, Youmine H, Gargadennec S, Martin-Chouly CAE, Christen MO, Legrand AB, Burgot JL. 203 10/ Remodeling of cerebral arterioles in hypertension secondary to inhibition of nitric oxide production. Chillon JM, Baumbach GL. 204 11/ Endothelin-1 receptor subtypes and calcium signalling in myocytes from large and small pulmonary arteries of the rat. Hyvelin JM, Marthan R, Savineau JP. 205 12/ Enoxaparin treatment of cerebral edema after photothrombotic injury in the rat.

Pratt J, Boudeau P, Uzan A, Stutzman JM. 206

Session 22 : Pharmacologie cardiovasculaire

Abstracts

Modérateurs :???

1/ Differential electrophysiologic effects of dolasetron, ondansetron and granisetron on cardiac action potentials recorded from rabbit purkinje fibers and ventricular muscle. Adamantidis MM, Dumotier BM, Bordet RC, Dupuis BA. 207 2/ Cisapride effects on postrest action potential duration in isolated rabbit ventricular muscle : No evidence for reverse use-dependent block. Dumotier B, Adamantidis M, Bastide M, Bordet R, Dupuis B. 208 3/ Block of inward rectifier potasium current, IK1, by cisapride in rabbit ventricular myocytes. Bastide M, Adamantidis M, Dumotier B, Bordet R, Dupuis B. 209 4/ Effects of prostanoids on the spontaneous beating rate of neonatal rat cardiac myocytes. Mechiche H, De Koker C, Millart H, Devillier P. 210 5/ Ischaemia-induced noradrenaline release is enhanced by 2-adrenergic receptor stimulation. Mazenot C, Durand A, Ribuot C, Godin-Ribuot D. 211 6/ Role of spinal nicotinic receptors in cardiovascular effects of dopaminergic agonists. Robein-Dobremez MJ, Demenge P. 212 7/ Blocking action of the selective ß3-antagonist SR59230A on ß3-adrenoceptor mediated cardiovascular and metabolic effects in dogs. Pelat M, Verwaerde P, Galitzky J, Langin D, Senard JM, Berlan M, Montastruc JL. 213 8/ Effects of sumatriptan and 5-CT on the saphenous vein, studied in vivo by an ultrasonic echo-tracking device in dogs and rabbits. Vayssettes-Courchay C, Ragonnet C, Coutant S, Verbeuren TJ. 214 9/ Amifostine effects on doxorubicin-induced cardiotoxicity using perfused isolated rat heart. Nazeyrollas P, Prévost A, Baccard N, Manot L, Devillier P, Millart H. 215 10/ Involvement of the tetraspanin CD9 in tyrosine kinase activation by beta1 integrins duringcollagen latrix reorganization mediated by human vascular smooth muscle cells in culture. Scherberich A, Moog S, Haan-Archipoff G, Azorsa D, Lanza F, Beretz A. 216 11/ Heat stress and myocardial protection in the rat. Joyeux M, Godin-Ribuot D, Demenge P, Ribuot C. 217 12/ Bertosamil alters the Ca2+-dependent processes which regulate L-Type Ca2+ current in human atrial myocytes.

Tessier S, Mercadier JJ, Hatem S. 218

Session 23 : Neuro-pharmacologie

Abstracts

Modérateurs :??? 1/ The analgesic activity of nasal morphine in mice increases with SMBV nanoparticles. Betbeder D, Sperandio S, de Nadaï J, Zajac JM, Francés B. 219 2/ Involvement of N-type calcium channels in hypothermic effects of neuropeptide FF in mice. Gelot A, Dupuy P, Francés B, Zajac JM. 220 3/ Are tachykinins involved in allodynia developped in chronic pain due to diabetes ? Coudore-Civiale MA, Courteix C, Eschalier A, Fialip J. 221 4/ Serotonin-dependent control of the electrophysiological activityof central serotoninergic neurons in the 5-HT1B-/-knock-out mouse. Evrard A, Hamon M, Adrien J. 222 5/ Effects of chronic ultramild stress (CUMS) on serotonin activity in mice brain. Lanfumey L, Pardon MC, Hanoun N, Laaris N, Fattaccini CM, Hamon M, Cohen-Salmon C. 223 6/ Biochemical and electrophysiological characterization of the 5-HT1A agonist properties of bay x3702. Le Poul E, Laaris N, Hanoun N, Fattaccini CM, Hamon M, Lanfumey L. 224 7/ 5-HT2 receptor stimulation in the nucleus tractus solitarius exerts a facilitatory influence on the baroreceptor reflex in rats. N’Diaye A, Sévoz-Couche C, Hamon M, Laguzzi R. 225 8/ Comparison between nociceptin and nociceptin (1-13)-nh2 on nociception and locomotion. Florin S, Suaudeau C, Meunier JC, Costentin J. 226 9/ Effects of sub-chronic and long term administration of antidepressant drugs on serotoninergicand dopaminergic parameters in various brain areas and in platelet serotonin in mice. Alvarez JC, Sanceaume M, Collignon I, Advenier C, Spreux-Varoquaux O. 227 10/ Serotonin, through 5-HT1A receptors, is involoved in mast cell degranulation-induced delayed rectal allodynia in rats. Coelho AM, Fioramonti J, Buéno L. 228 11/ Dorsal medullary 5-HT3 receptors and sympathetic premotor neurones. Sevoz-Couche C, Nosjean A, Franc B, Hamon M, Laguzzi R. 229 12/ Post-diaphragmatic vagotomy effect on fedotozine granisetron and ML10302 visceral analgesic activity in rats. Périé-Phagouapé N, Biosa S, Bouyssou T. 230 13/ Characterization of a 5-HT1A antagonist and a model of 5-HT1B “Knockout” mice : Application to the study of antidepressant drug. Trillat AC, Gardier AM, Jacquot C. 231 14/ Augmentation of antidepressant pharmacotherapy A preclinical approach using the mouse forced swimming test. Redrobe JP 232 15/ Mice prone and resistant to helplesness in the tail suspension test exhibit marked differences in other behavioral tests.

Vaugeois JM, Passera G, Costentin J. 233

Session 24 :Neuro-pharmacologie, inflammation.

Abstracts

Modérateurs :??? 1/ Role of peripheral inflammation in hyperalgesia induced by magnesium depleted diet in rats. Begon S, Eschalier A, Alloui A, Dubray C. 234 2/ Involvement of a primary immunization and IL-1ß and IL-6 in release of hypothalamic serotonin in the rat : modulation of antibody production. Khan Shaghaghi E, Wu Y, Pallardy M, Jacquot C, Gardier AM. 235 3/ Evidence that somatostatin-14 modulates the activity of the gaba-A receptor complex. Alfaidy N, Vincens M. 236 4/ Melatonin is neuroprotective in a brain injury model in mice. Mésenge C, Verrecchia C, Boulu RG, Plotkine M. 237 5/ Levodopa induces dopamine D3 receptor expression in 6-OHDA denervatedstriato-nigral pathway : Role of substance P and dynorphin in behavioral sensitization. Bordet R, Ridray S, Sokoloff P, Schwartz JC. 238 6 / Heat stress-induced B1 receptors in the rat Lagneux C. 239 7/ Involvement of tachykinin receptors in the sensitization to cow’s milk proteins in guinea-pigs. Gay J, Fioramonti J, Garcia-Villar R, Buéno L. 240 8/ Heat stress-induced B1 receptors in the rat.

Lagneux C, Godin-Ribuot D, Ribuot C, Demenge P. 241

Session 25 : Pharmacologie clinique, Pharmaco-épidémiologie, Pharmacocinétique

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Abstracts

Modérateurs :??? 1/ Cytochrome P450 2C and 3A catalyze the metabolism of Zopiclone. In vitro study in human liver microsomes and recombinant human enzymes. Becquemont L, Mouajjah S, Beaune P, Jaillon P. 242 2/ Are cysteamine hydrochloride, cysteamine bitartrate and phospho-cysteamine equivalent? Sudy in healthy volunteers. Tennezé L, Daurat V, Tibi A, Chaumet-Riffaud P, Funck-Brentano C. 243 3/ Amiodarone pharmacokinetic irregularities in healthy male volunteers after a single oral loading dose. Libersa C, Motte K, Guedon-Moreau L, Vinner E, Lhermitte M. 244 4/ Inhibition of amiodarone metabolism induced by grapefruit juice : first report. Libersa C, Brique S, Caron J, Motte K, Guedon-Moreau L, Vinner E, Lhermitte M. 245 5/ Timing errors in drug intake and pharmacologic response : a simulation study at steady state. Nony P, Cucherat M, Boissel JP. 246 6/ Plasma itraconazole concentrations in patients with neutropenia : Advantages of a divided daily dosage regimen. Poirier JM, Hardy S, Isnard F, Cheymol G, Jaillon P. 247 7/ Déterminants de la prescription ambulatoire des inhibiteurs de l’enzyme de conversion dans l’insuffisance cardiaque sévère : l’étude épical. Echemann M, Briançon S, Juillière Y, Virion JM, Mertès PM, Zannad F. 248 8/ Hospital admission and psychotropic drug use : a survey in an emergency department in a French University Hospital. Lapeyre-Mestre M, Cinq-Frais C, Ducasse JL, Montastruc JL. 249 9/ Urinary cotinine assays : a need for individual transdermal nicotine therapy in smoking cessation – a plot 405 patients study. Bustany P, Le Maître B, Cleren P. 250 10/ Acute dose of haloperidol 3MG as a model of behavioral and psychomotor deficit in healthy volunteers, and the effects of nicergoline. Soubrouillard C, Darmon A, Jouve E, Bertholom N, Mestre D, Audebert C, Dib M, Blin O. 251 11/ Comparaison de la tolérance de la bromocriptine (parlodel®) en monothérapie ou en association précoce à la L-dopa chez le parkinsonien. Destée A, Bordet R, Defebvre L, Rogelet P, Goulley F. 252 12/ Lack of cardiovascular and hormonal responses after acute tacrine administration in healthy volunteers. Lazartigues E, Brefel-Courbon C, Thalamas C, Senard JM, Tran MA, Elbaz M,Montastruc JL, Rascol O. 253 13/ Analgesic effect of somatostatin analogue in acromegalic patients treated. Tielmans D, Cunin G, Warnet A, Vincens M. 254 14/ Effects of lorazepam on emotional reactivity, performance and vigilance, in subjects of high and low anxiety. Garcia C, Philippot P, Jouve E, Bruguerolle B, Blin O. 255 15/ Effects of immunosuppressive drugs in kidney transplant recipients (treated with azathioprine) compared with insufficient renal subjects. Maurel V, Mousson C, Mounié J, Tanter Y, Rifle G, Escousse A. 256 16/ NSAIDs use and helicobacter pylori infection in duodenal ulcer perforation. de Korwin JD, Grosdidier G, Lozniewski A, Vuillaume JM, Conroy MC, Tréchot P, Weber M, Duprez A. 257 17/ Quality assurance role of Clinical Research Assistants (CRA) in therapeutic trials and pharmaco-epidemiological studies. Observations taken from five clinical study audits carried out in France. Simon T, Chanton E, Guillardeau A, Jaillon P. 258 18/ Principles of computer-assisted teaching use in pharmacology. Le Normand Y. 259 19/ Enseignement de la pathologie induite par les médicaments : L’expérience de la faculté de médecine de Dijon.”

Sgro C, Hillon P, Besancenot JF, Huet F, Escousse A. 260

Session 26 : pharmacologie broncho-pulmonaire

Abstracts

Modérateurs :??? 1/ Effects of genistein, a tyrosine kinase inhibitor, on the guinea pig isolated trachea. Corompt E, Caron F, Bessard G, Devillier P. 261 2/ Interactions between c-fibers, cholinergic fibers and mast cells in tracheally perfused rabbit lungs. Nemmar A, Delaunois A, Gustin P. 262 3/ Effects of ozone on the mechanical properties and hemodynamics of isolated perfused rabbit lungs. Delaunois A, Segura P, Vargas M, Montano L, Gustin P. 263 4/ Compared effects of isoprenaline, salbutamol and SR 59104A on potassium channels in hypoxic pulmonary vasoconstriction. Dumas JP, Goirand F, Bardou M, Dumas M, Rochette L, Advenier C, Giudicelli JF. 264 5/ Characterization of atrial natriuretic factor-mediated relaxaton on guinea-pig trachea. Corompt E, Bessard G, Devillier P. 265 6/ Indomethacin and glucocorticoids inhibit bradykinin B2 receptors gene over-expression induced by IL1-ß in human bronchial smooth muscle cells.

Schmidlin F, Loeffler S, Brandenberger A, Landry Y, Gies JP. 266

Session 27 : Oncologie et thérapeutique anti-infectieuse.

Abstracts

Modérateurs :??? 1/ Interaction between ERBB-2 (HER2/NEU) and human breast cancer resistance to chemotherapy. Martin EC, Liva S, Sastre-Garau X, Barbaroux C, Bouchind’homme B, Dieras V, Magdelénat H, de Cremoux P. 267 2/ Activation of anti-tumor cytotoxic T lymphocytes by non-natural ligands : Structural and pharmacological studies.” Ayyoub M, Monsarrat B, Mazarguil H, Gairin JE. 268 3/ DNA-Dependent protein kinase activity (DNA-PK) is determinant in the response of normal and tumoral human primary b-lymphocytes to nitrogen mustards. Muller C, Christotodoulopoulos G, Panasci L, Salles B. 269 4/ Inclusion complex of amphotericin B with cyclodextrin. Antifungal activity and cellular accumulation potentiation of cisplatin. Rolland JY, Correia M, Lopez J, Beltramo JL, Belon JP, Chauffert B. 270 5/ Apoptosis signaling in neoplastic cells : A new perspective in anticancer pharmacology. Jaffrézou JP. 271 6/ Vancomycin delivery from a poloxamer gel matrix. Veyries ML, Faurisson F, Couarraze G, Geiger S, Lacroix C, Rouveix B. 272 7/ Effects of tetracyclin and chloramphenicol on ion transport in human nasal epithelial cells. Sari A, Hauser JJ, Chevalier D, Darras C, Salomez MD, Jacquesson JM, Matran R. 273 8/ Dose-effect relationships between cefepime (Cpm), cefpirome (Cpr) or imipenem (Imp)   and 2 clinical outer membrane proteins (omp) mutant strains of enterobacter cloacae in the mouse thigh infection model. Garraffo R, Fosse T, Roptin C, Cassar M, Luciano C. 274 9/ Interactions between cisplatin, carboplatin and oxaliplatin and L-methionine in vitro ; possible pharmacological consequences.

Heudi O, Mercier-Jobard S, Cailleux A, Allain P. 275